2012 Scientific Report - Queensland Children's Medical Research ...

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QCMRI Director’s Report ........................................................................................................... 3 Cancer and Cell Biology ............................................................................................................ 4 Children’s Cancer Research Laboratory ........................................................................... 5 The Developing Brain, Growth and a Healthy Start to life ......................................................... 10 Endocrinology and Diabetes Research Group ................................................................. 11 Feeding and Development Therapies Group ................................................................... 17 Infection, Inflammation and the Environment .......................................................................... 20 Cough, Asthma and Airways Research Group ................................................................. 21 Respiratory infection Outreach and Research Team ........................................................ 29 Children’s Lung, Environment and Asthma Research Group ............................................. 38 Airways Infections, Inflammation and Cystic Fibrosis Group ............................................ 50 Queensland Paediatric Infectious Diseases (QPID) Laboratory ......................................... 54 Burns, Trauma and the Critically Ill ........................................................................................... 65 Centre for Children’s Burns and Trauma Research ........................................................ 66 Innovative, Evidence Based Health Care and Delivery ................................................................ 74 Department of Nursing Research, Royal Children’s Hospital ........................................... 75 Centre for Online Health ............................................................................................... 80 Children’s Allied Health Research ................................................................................... 92 Biostatistics and Epidemiology Unit ............................................................................. 100
Director’s Message The Queensland Children’s Medical Research Institute (QCMRI) had a highly productive year in 2011, expanding to nearly 200 researchers, research higher degree students and support staff. QCMRI researchers achieved outstanding success in the 2011 NHMRC project and fellowship funding rounds, with our researchers involved in projects totalling more than $8.8 million. QCMRI researchers 2012 was another are now productive lead investigators year for on the projects QCMRI. totalling The Institute Director’s more than grew $4.8m, in numbers Message with Dr again Kerry-Ann in 2012, O’Grady with over awarded 230 researchers, the single largest research project higher grant degree of any students University and of support Queensland staff researcher, now members a of fantastic the Institute. outcome. The Researchers Institute had from a 100% QCMRI success achieved rate outstanding applications success to the in NHMRC’s the 2012 fellowship NHMRC was another schemes, funding productive rounds. with year In for the QCMR particularly the project pleasing and fellowship outcomes categories, for our early our career researchers researchers. were In involved 2011, with over QCMRI in successful 230 researchers, applications research higher degr produced totalling $8.59 170 peer million. reviewed QCMRI manuscripts, researchers books are and lead book investigators chapters. the Several Institute. on projects were published totalling high over impact $3.68m, journals with special including mention the New to England Professor Journal Claire of Wainwright Medicine, Lancet, who Nature was successful Genetics in and 2 the project Journal grant applications of the American as CIA, Medical worth Association. a combined QCMRI total of researchers $1.71 million. were Researchers also involved from in QCMRI the achieved outstanding supervision of 73 research higher degree students in 2011 and a further project 10 students and fellowship graduated categories, our resear during Also of the note year. was the awarding of a $2.5 million NHMRC Centre totalling of Research $8.59 million. Excellence QCMRI to researchers are le QCMRI’s Professor Anne Chang in the area of Indigenous Children’s $3.68m, Health. with special mention to Professor Claire QCMRI also launched its Children’s Health and Environment Program (CHEP) in 2011. Under grant applications as CIA, worth a combined tota Professor QCMRI students Peter Sly’s were directorship, also highly CHEP successful aims to in become obtaining one prestigious of Australia’s NHMRC major Scholarships, research bodies with for 3 environmental scholarships awarded issues affecting to QCMRI children’s in the 2012 health. round. This $5m UQ were initiative awarded Also is a of collaboration 7 note of these was the scholarships between awarding the in of a $2.5 million N QCMRI, total, so UQ’s QCMRI School students of Population and their Health, supervisory Global teams Change should Institute, be QCMRI’s National very proud Research Professor their Centre Anne efforts for Chang when in the area of Ind Environmental put into this context. Toxicology and Faculty of Health Science. QCMRI students were also highly successful in o The In terms Institute of also research saw research income successfully more broadly, translated QCMRI to outcomes researchers scholarships in 2011. were Examples Chief awarded Investigators include to QCMRI the on in the 2012 rou uptake projects of totalling recommendations more than for $40 the optimal million (life first-aid of project), in burns developed with total, 2012 by so income QCMRI of Burns students approximately and their supervisory t researchers $11.5m and by in the excess Australia of $8.5m and New where Zealand QCMRI Burns researchers Association, were St lead put John’s into investigator. Ambulance this context. and other organisations; research that has helped to further define the clinical role of bronchoalveolar lavage In 2012, QCMRI researchers produced 184 peer reviewed manuscripts, (BAL) in cystic fibrosis; development of new National and International In terms guidelines of with research an additional on the income treatment more 22 broadly, QCM books and book chapters. A number of these manuscripts of bronchiectisis; and the demonstration of safety and efficacy of Influenza projects were published vaccines. totalling in more high than impact $40 million (life of p journals including the Lancet, Nature Genetics and the Journal $11.5m of and the in American excess of Medical $8.5m where QCMRI re Association. I would also like to thank the Children’s Health Foundation Queensland (CHFQ) and their donors for their QCMRI continued researchers support were of involved our Institute. in the The supervision CHFQ works of tirelessly 70 research to In 2012, raise higher the QCMRI degree funds researchers we students need to (PhD produced XXX p invest and MPhil) in research. in 2012 and a further 8 students completed their studies XX books during and book the course chapters. of the A number of these year. journals including the Lancet, Nature Genetics a While the QCMRI is only two years young, it has very quickly cemented its place as a leader in Association. children’s QCMRI continues health research. to receive None of wonderful the achievements support or from opportunities the Children’s I have discussed Health would Foundation have been Queensland possible and without their the donors. hard work Much and of dedication the Institute’s of our success team of is QCMRI passionate based researchers this support were and and involved their in the supervi support entire QCMRI staff. QCMRI community researchers is greatly continue appreciative to push boundaries of the Foundation’s and and achieve MPhil) ongoing real outcomes 2012 commitment and for a further to 8 students com health supporting and well-being research at of QCMRI. children in Queensland and further afield. year. Professor Keith Grimwood Director 2011 was an extremely successful year for the QCMRI and has provided us with solid foundations for an even greater 2012. Professor Keith Grimwood Professor Keith Grimwood Director - Director QCMRI Scientific Report 2011 3
Page 4 and 5: QCMRI Scientific Report 2011 4
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Page 22 and 23: Awards & Achievements ‣ Helen Pet
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Publications Peer Reviewed Manuscri
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Queensland Paediatric Infectious Di
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2011- 2015 Hospital Foundation NHMR
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Publications Peer Reviewed Manuscri
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22. Lambert SB, Ware RS, Cook AL, M
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44. Whiley DM, Jacob K, Nakos J, Bl
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National and International Collabor
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Centre for Children’s Burns and T
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Years Grant Agency 2012 RCH Foundat
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Staff Profile Name Prof Roy Kimble
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‣ 2009-present: Professor Zee Upt
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QCMRI Scientific Report 2011 88 QCM
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Professor Jeanine Young, appointed
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6. Watson K, Young J, Barnes M. (20
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Centre for Online Health Message fr
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Summary of Research Activities and
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This project represents a significa
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13. Fatehi, F. and R. Wootton (2012
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Ms Joanne Grey Senior Research Comm
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‣ Queensland Cerebral Palsy and R
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Children’s Allied Health Research
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2011- 2013 Foundation for Children
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18. Wallen, M. A., & Ziviani, J. M.
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Research Degrees Ongoing Name Super
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Biostatistics and Epidemiology Unit
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6. Benfer, KA; Weir, KA; Bell, KL;
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Infectious Diseases (ORChID): a dyn
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