2012 Scientific Report - Queensland Children's Medical Research ...

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disease lead by Dr. Andrew Moore. Over 12,000 vials containing patient samples are currently held in the QCTB collection, stored at ultra-low temperatures in multiple geographic locations. In addition to continued involvement in the projects of local and national collaborators (studying both solid tumour and leukemic disorders), 2012 saw the QCTB begin supporting international cancer biology projects. New collaborations were established with two independent research groups in the U.S.A. (both studying the brain tumour medulloblastoma), a large research consortium based in Canada (studying medulloblastoma and ependymoma), and two research groups in the U.K. (studying high grade glioma and rhabdomyosarcoma). The tumour bank provides such researchers not just with biological resources such as tissue, DNA and RNA, but works actively with the project coordinators to provide valuable matched clinical data tailored to the needs of each individual project. A number of our collaborative projects will run long-term over coming years, with the QCTB providing further bio-specimens and scientific support as new patients of interest are diagnosed at the Royal Children’s Hospital. Such projects highlight the important long term role that biobanks play in adding power to investigations of the most common paediatric cancers and enabling meaningful study of rare disease types. Such studies will ultimately lead to better outcomes for future children with cancer. The QCTB continues to maintain a close working relationship with the Clinical Research Office in the Division of Oncology at the Royal Children’s Hospital, providing laboratory services that allow the hospital to take part in a large number of clinical trials. These are typically large multicentre trials that aim to assess the safety and efficacy of new treatments for haematological disorders and cancer. Awards Dr Andrew Moore ‣ Australian and New Zealand Children’s Haematology and Oncology Group (ANZCHOG) Annual Scientific Meeting 2012. Awarded one of two best oral abstract prizes. ‣ Leukaemia Foundation Young Investigator Award 2012. This was the major prize for the 2012 New Directions in Leukaemia Research Meeting, awarded to the best research contribution based on assessment of abstract and poster or presentation by the judging panel at the meeting. QCMRI Scientific Report 2012 6
Research Grants and Contracts Years Grant Agency Chief Investigators 2010- QCMRI/ Children’s A/Prof. A 2015 Health Foundation Hallahan Queensland Title Tumour Bank - Infrastructure Funding Amount $401,911 2012- 2013 The BrainChild Foundation Dr. W Ingram Towards Better Outcomes For Children With Brain Tumours – Advancement Of Multiple Research Studies Using Banked Specimens $25,000 2012- 2016 NHMRC Dr A Moore The role of Survivin and XIAP (Xlinked inhibitor of apoptosis protein) as biomarkers and therapeutic targets in paediatric acute myeloid leukamia $248,424 2012- 2016 Children’s Health Foundation Queensland / QCMRI Dr A Moore A study to assess the mechanisms of cell death in acute myeloid leukaemia. $506,615 2012 Pfizer Australia Dr A Moore The role of Survivin and XIAP (Xlinked inhibitor of apoptosis protein) as biomarkers and therapeutic targets in paediatric acute myeloid leukamia 2012 ANZ Trustees Dr A Moore The role of Survivin and XIAP (Xlinked inhibitor of apoptosis protein) as biomarkers and therapeutic targets in paediatric acute myeloid leukamia $50,000 $50,000 Publications Peer Reviewed Manuscripts 1. Bavetsias V, Crumpler S, Sun C, Avery S, Atrash B, Faisal A, Moore AS, Kosmopoulou M, Brown N, Sheldrake PW, Bush K, Henley A, Box G, Valenti M, de Haven Brandon A, Raynaud FI, Workman P, Eccles SA, Bayliss R, Linardopoulos S, Blagg J. Optimization of imidazo [4,5-b]pyridine-based kinase inhibitors: identification of a dual FLT3/Aurora kinase inhibitor as an orally bioavailable preclinical development candidate for the treatment of acute myeloid leukemia. J Med Chem2012; 55: 8721-34 QCMRI Scientific Report 2012 7
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