Sight and Life Magazine 1/2011

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12 SIGHT AND LIFE STATEMENTcolonic microflora in African children to create a potentiallymore pathogenic profile. If this is confirmed, it could help to explainthe reported adverse effects of iron supplementation andbolus doses of iron.The other potential mechanism discussed is the formationof non-transferrin-bound iron (NTBI). Recently presented dataon the formation of NTBI 8 after administration of iron in womenwith low iron status (NTBI formation monitored over eight hours),showed that the highest NTBI concentrations were produced bya 60 mg dose without food, followed by 60 mg and 6 mg withfood. These first data indicate that iron administered with foodand through fortification (rather than supplementation) resultedin lower NTBI formation.“The two-step approach of optimizingthe MNP formulation for malariaendemic areas is expected to be saferthan typically used iron doses”In conclusion, based on current knowledge, the two-step approachof optimizing the MNP formulation for malaria endemic areasis expected to be safer than typically used iron doses (12.5 mg).The reduction of the iron dose to levels closer to the amount of ironprovided in food fortification helps to reduce the amount of unabsorbediron in the intestine. Meanwhile, using a highly bioavailableiron compound in combination with iron absorption enhancersis crucial to supplying the individual with the iron needed.References01. WHO/WFP/UNICEF Joint Statement. Preventing and controllingmicronutrient deficiencies in populations affected by an emergency.Multiple vitamin and mineral supplements for pregnant andlactating women, and for children aged 6 to 59 months. WHO,2007.02. Sazawal, S, Black R, Ramsan M et al. Effects of routine prophylacticsupplementation with iron and folic acid on admission to hospitaland mortality in preschool children in a high malaria transmissionsetting: community-based, randomized, placebo-controlled trial.Lancet 2006;367(9505):133–4303. Oppenheimer SJ. Iron and its relation to immunity and infectiousdisease. J Nutr 2001;131(2S-2):616S-633S; discussion 633S–635S.04. Ojukwu J, Okebe J, Yahav D et al. Oral iron supplementation forpreventing or treating anemia among children in malaria-endemicareas. Cochrane Database Syst Rev 2009;(3): CD006589.05. WHO. Conclusions and recommendations of the WHOConsultation on prevention and control of iron deficiency in infantsand young children in malaria-endemic areas. Food Nutr Bull2007;28:S621–S706. Hurrell, R, Ranum P, de Pee S et al. Revised recommendations foriron fortification of wheat flour and an evaluation of the expectedimpact of current national wheat flour fortification programs.Food Nutr Bull 2010;31(1 Suppl):S7–2107. Zimmermann, M, Chassard C, Rohner F et al. The effects of iron fortificationon the gut microbiota in African children: a randomizedcontrolled trial in Côte d'Ivoire. Am J Clin Nutr 2010;92:1406–15.08. Egli I, Brittenham G, Zeder C et al. The influence of supplementationand fortification iron doses on the formation of plasma-nontransferrin-boundiron. (UC Davis) Conference on Bioavailability,Asilomar, CA, September 26–30, 2010 (only abstract available)
SIGHT AND LIFE | VOL. 25 (1) | 201113The “Sight and Lifein My Life”Essay CompetitionIn the last issue of the magazine, we launched the Sight and Life inMy Life Essay Competition. Its aim was to find out how Sight and Life hasplayed a part in readers lives, as part of the organization’s 25thanniversary.The closing date for the competition was 15 March 2011 and we havereceived many wonderful stories. We have been delighted with theentries we have received and are looking forward to sharing these withyou in future issues. We are now in the process of reading and judgingthe entries and will be contacting the winners and those who sent ushighly commended entries later this summer.We have received entries from many countries, from Nigeria to SriLanka. Many fascinating photographs and even some original artworkhas come our way, such as the picture here by Dr Narendra Kumar,which is the cover of her booklet that helps children and families inIndia.We would like to say a very heartfelt thank you to all you who enteredthe competition. We appreciate the time you have spent on writing yourentries and would also like to thank you for all the amazing good workyou do in your communities.With warmest wishesThe Sight and Life Team
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Page 6 and 7: 6What is abrand ?It would be imposs
Page 8 and 9: 8EDITORIALOur history between two c
Page 10 and 11: 10 SIGHT AND LIFE STATEMENTSight an
Page 16 and 17: 16THE IMPORTANCE OF VITAMIN AThe Im
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Page 30 and 31: 30THE FEASIBILITY OF DELIVERING VIT
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80nd Life Special Research Grant 20
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86 WHAT'S NEWFood and nutrition sec
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88 WHAT'S NEWricesYet Again …09Ri
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90 WHAT'S NEWA2Z: The USAID Micronu
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92 WHAT'S NEW4ne Collaboration Join
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94WHAT'S NEW17Atmala’s Medal of S
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96Comments on the Comparison of the
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98Editor’s note: Sight and Life r
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100 PUBLICATIONSOmega-3Fatty Acids
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Sharingknowledgefor improvednutriti
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Buildingbridgesfor betternutrition.
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