Mathematics and transfusion medicine - Blood Transfusion

Giampaolo A et al.late haemolysis0.3%fever46.9%urticaria36.5%HIV0.1%Volume overload2.1%GVHD0.1%TRALI0.1%other4.1%shivers4.6%nausea, vomiting2.1%anaphylaxis2.2%acute haemolysis0.9%Figure 2 - Adverse reactions 2005Table II - PETRA forms receivedAbruzzo 6Campania 4Emilia Romagna 65Friuli Venezia Giulia 13Lazio 25Liguria 18Marche 57Piemonte 483*Puglia 8Sardegna 4Sicilia 44Autonomous Province of Bolzano 1Veneto 257Military structures 1(*) See "Methods" sectionPETRA 2004-2005Adverse reactionsOverall, 986 forms were returned (Table II), ofwhich 871 reported adverse reactions and 63 reportednear miss errors or errors; 52 forms could not beevaluated (Figure 3A).In 848 of the forms, the adverse reaction wasattributed to the transfusion; in 65% of these (n=555)the association with the transfusion was stated to bestrong (certain or probable cause); only these weretaken into consideration for the analysis (Figure 3B).As far as regards the severity of the reactions, thesecaused mild symptoms in 65.8% of the reported casesand long-term morbidity in 31.9%, were lifethreateningin 2.1%, and led to death in 0.2%. Figure4 shows the severity of the reactions in the events inwhich the transfusion was probably or certainly thecause of the reaction. The only death was due to anacute haemolytic reaction caused by ABOincompatibility. Life-threatening events wereanaphylactic reactions (n=5), volume overloadsyndrome (n=2), TRALI (n=1), febrile reaction (n=1),urticarial reaction (n=1) and reactions defined as"other" (n=2).Almost all the adverse reactions reported wereacute; only three were delayed (late haemolysis). Asregards the type of reaction, 46.4% were of an allergicnature (urticaria and anaphylactic reactions) and33.9% of a febrile type (Figure 5).The type of blood component involved in theadverse reactions was reported in 92.9% of the cases70Blood Transfus 2007; 5: 66-74 DOI 10.2450/2007.0001-07066-074_hassan.p65 7005/07/2007, 10.44