Mathematics and transfusion medicine - Blood Transfusion

Bocciardo L et alTable IV - Consumption of plasma derivatives by the Gaslini InstituteConsumption of Consumption of Consumption ofalbumin intravenous IgG antithrombin III2001 38,580 g 6,024 g 405,000 UI2002 34,190 g 8,445 g 386,000 UI2003 43,290 g 7,830 g 388,000 UI2004 44,000 g 6,476 g 550,000 UI2005 43,762 g 8,579 g 530,500 UITable V - Theoretical coverage of the requirements of plasma derivatives2001 2002 2003 2004 2005Albumin 82.62% 97.47% 79.18% 84.32% 91.63%Intravenous IgG 61.38% 45.78% 50.78% 66.45% 54.22%Antithrombin III 23.94%% (with reference to 2001)1601401201008060402002001 2002 2003 2004 2005YearAlbuminIntravenous IgGAntithrombin IIITotalFigure 5 - Requirements for albumin, intravenous IgG and antithrombin III, normalised to 2001 levels. Thevirtual overall requirements, calculated as the sum of the three products, is also reported, againnormalised to 2001 levelsantithrombin III was distributed after third party processingstarting from March of the same year.Finally, for each blood derivative considered, weevaluated the amount of plasma necessary to meet thetheoretical requirements.The graph in figure 6 shows the trends in the amountsneeded for each of these derivatives each year.It is clear from this that the blood derivative giving riseto the greatest request for plasma is intravenous IgG.DiscussionIn line with the national plan for reaching selfsufficiencyin plasma derivatives, the SIMT of the GasliniInstitute for children defined a plan to increase the volumeof plasma to send for industrial fractionation as an objectiveof its Quality System. This led to the definition of newprocedures for both production and clinical use of plasma.The increase in plasma production was obtainedwithout compromising the primary objective of the SIMT90Blood Transfus 2007; 5: xx-xx DOI 10.2450/2007.0033-06085-92_bocciardi.p65 9009/07/2007, 9.47