LC/MS/MS Analysis of Gabapentin, Benzodiazepines, and Opiates
LC/MS/MS Analysis of Gabapentin, Benzodiazepines, and Opiates
LC/MS/MS Analysis of Gabapentin, Benzodiazepines, and Opiates
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Amphetamine Summary Excellent sensitivity at the level <strong>of</strong> 5ng/mL Good separation from a column packed with afluorinated phenyl phase Detection limits will be at least the low ppb levels for allcompounds All 6 drugs can be run simultaneously in a 6 min. run Good linearity <strong>of</strong> calibration curves ranging from 5-10,000 ng/mL<strong>Analysis</strong> <strong>of</strong> Carboxy-THCby<strong>LC</strong>/<strong>MS</strong>/<strong>MS</strong>Carboxy -THC Experimental ConditionsChromatograms – Carboxy - THC ESI Negative. <strong>LC</strong> Conditions: Column: Varian Pursuit Diphenyl50X2mm, 3μ Flow Rate: 0.2 mL/min A: Water B: Methanol Time %B 0:00 40 0:30 40 1:00 95 3:00 95 3:01 40 6:30 40 Injection Volume, 20 μL Mass Spec conditions: Argon pressure: 2.0 mtorr Q1/Q3 peak width: 1.0/1.0amu Transitions: 343.50 -> 299 CE 17.5 352.50 -> 308 CE 20.5 SamplesIn a complicated matrixsolutionSt<strong>and</strong>ard Solutions preparedby serial dilutions in DI water50 μL IS added to 1 mL <strong>of</strong>sampleCarboxy-THC – 10 ng/m<strong>LC</strong>arboxy-THC – 1 ng/mL
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