LC/MS/MS Analysis of Gabapentin, Benzodiazepines, and Opiates
LC/MS/MS Analysis of Gabapentin, Benzodiazepines, and Opiates
LC/MS/MS Analysis of Gabapentin, Benzodiazepines, and Opiates
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IonizationSourceDetector<strong>LC</strong>/<strong>MS</strong>/<strong>MS</strong> AnalyzerQ1Mass AnalyzerVacuum SystemQ3Mass AnalyzerQ2Collision Ce<strong>MS</strong>/<strong>MS</strong> what’s that? <strong>MS</strong>/<strong>MS</strong> is when you have more than one step <strong>of</strong>mass filtration/separation <strong>and</strong> an additional step<strong>of</strong> fragmentation. <strong>MS</strong>/<strong>MS</strong> is used to give an additional level <strong>of</strong>confirmation to an analysis or when very specificresults are required. <strong>MS</strong>/<strong>MS</strong> can also help determine the molecularstructure <strong>of</strong> a molecule.Q2- CurvedCollision CellTriple Quad SRMVarian <strong>MS</strong> Quad: Strong PointsUnique Curved (180°) Collision CellQ1MRM or SRMIonSourceQ1Q3First transitionQ1Q2- CurvedCollision CellExample with a second transition (different precursor <strong>and</strong> fragment ions)Q3Q2Q1Q2- CurvedCollision CellQ3IonsMRM - <strong>of</strong>ten used to describe “Multiple” Reaction Monitoring.SRM – preferred term. Selected Reaction Monitoring (not single).Relating to data acquired from specific product ions correspondingto m/z selected precursor ions.(IUPAC recommendations, www.msterms.com).DetectorQ3
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