LC/MS/MS Analysis of Gabapentin, Benzodiazepines, and Opiates
LC/MS/MS Analysis of Gabapentin, Benzodiazepines, and Opiates
LC/MS/MS Analysis of Gabapentin, Benzodiazepines, and Opiates
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<strong>MS</strong><strong>MS</strong> Using a Curved Collision CellIonSourceQ1• Increased S/N− removal <strong>of</strong> photons, metastable ions& high energy charged droplets fromion detectorQ2NeutralNoise notdeflectedWhy <strong>MS</strong>/<strong>MS</strong>Why <strong>MS</strong>/<strong>MS</strong> for <strong>LC</strong>/<strong>MS</strong>?for <strong>LC</strong>/<strong>MS</strong>?IonsDetectorQ3Limitation <strong>of</strong> API Interfaces Atmospheric Pressure Ionization (API) dominate <strong>LC</strong>/<strong>MS</strong> Electrospray (ES, ESI, APESI) Chemical Ionization (APCI) Photoionization (APPI) All API mechanisms are “s<strong>of</strong>t” Minimal fragment ions formed during ionizationTypically only molecular ion informationPseudo- or quasi-molecular ion(s) Minimal qualitative information for confirmationAdduct ions (Na, K, etc) are not useful forconfirmation1005077109141195EI Full Scan <strong>MS</strong> <strong>of</strong> ReserpineEI-GC/<strong>MS</strong> produces a wide range <strong>of</strong> ions“Information Rich”212226251265301359 381040 90 140 190 240 290 340 390 440 490 540 590(mainlib) Reserpine395HNOONO413 448608Electron Ionization spectrum from NIST; probe sample introductionOOOOOO
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