An attempt at an epidemiological explanation - Epib.nl
An attempt at an epidemiological explanation - Epib.nl
An attempt at an epidemiological explanation - Epib.nl
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Meningococcal disease in the Netherl<strong>an</strong>ds, 1958-1990T3ble 4. Rel<strong>at</strong>ive distribution of serotypcs <strong>an</strong>d sUhtypcs among scrogroup B meningococci recoveredfrom p<strong>at</strong>ients with meningococcal disease in the Netherl<strong>an</strong>ds between 1958 <strong>an</strong>d 1990(0 = 2357)D<strong>at</strong>a for year(s) of recoveryVariable 1958-61 1964-65 1970 1975 1980 1983 1985 1986 1987 1988 1989 1990No. of isol<strong>at</strong>eslost in storage 45 23 25 8 3 0 0 0 0 0No. of isol<strong>at</strong>estested 85 81 94 88 96 121 192 274 262 278 401 385Serotypes (%)1 6 6 1 5 6 0 5 0 0 1 1 52. 16 9 2 2 2 7 4 4 8 6 6 42b 2 15 63 39 31 5 3 6 2 2 2 24 4 15 7 11 11 28 35 38 44 47 44 4314 2 0 0 2 4 6 4 5 5 5 2 315 11 5 3 3 1 17 20 20 16 10 9 916 2 2 1 3 0 2 3 3 2 0 1 24/14 0 0 0 0 0 0 0 0 0 0 0 1Nonserotypeable 56 48 22 34 44 36 27 25 23 28 35 32SUbtypes (%)1'1.1 9 0 3 1 1 0 1 0 0 0 1 0P1.2 22 36 64 39 22 10 9 10 10 8 9 6P1.4 0 1 1 1 3 10 20 26 24 33 35 41P1.6 15 12 5 6 7 7 5 1 3 1 2 21'1.7 2 1 1 1 1 1 2 6 3 3 3 3P1.7,1 18 14 5 2 3 5 3 2 3 2 1 11'1.7,16 2 1 0 1 1 7 13 16 11 6 6 6P1.9 6 1 1 1 3 3 1 3 2 2 2 2P1.10 0 1 1 1 8 2 2 2 5 5 4 3P1.12 2 4 1 8 8 7 3 3 1 4 1 3P1.14 0 0 1 1 1 2 2 3 2 2 3 2P1.I5 0 10 1 9 13 12 16 9 14 8 6 5P1.16 5 2 0 7 2 10 11 6 10 6 11 9Other 2 1 2 0 0 1 1 0 0 0 0 0Nonsubtypeablc 15 15 13 22 26 22 15 13 12 21 16 19includes 1'1.4,16, 1'1.6,14, 1'1.6,16. 1'1.7,14, 1'1.12,2 (2 isol<strong>at</strong>es), 1'1.12,4 <strong>an</strong>d 1'1.12,14Serogroup B (1958-1990). The distribution of serotypes <strong>an</strong>d subtypes of all availableserogroup B isol<strong>at</strong>es obtained during 1958-1961, 1964-1965, 1970, 1975, 1980, 1983,<strong>an</strong>d 1985-1990 (n = 2357) is shown in Table 4. The rel<strong>at</strong>ive frequency of serotype 2bincreased from 2% during 1958-1961 to 15% during 1964-1965, just before the 1966epidemic, which was caused predomin<strong>an</strong>tly by serotype 2b isol<strong>at</strong>es." This serotypewas still found to characterize 63% of all serogroup B isol<strong>at</strong>es in 1970, after which itsfrequency dropped to 2% in 1990. Serotype 2a strains were recovered frequently from1958 to 1961, but their frequency fen after 1965. Until 1980 the frequency of recovery25
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