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Division of Bioconvergence TechnologyBioMonitoringResearch CenterRESEARCHERSMin-Gon Kim mgkim@kribb.re.krHigh sensitivity detection technology for biomonitoringBioarray technology for rapid and massive analysis ofbiomaterialsYong Beom Shin ybshin@kribb.re.krDeveloping analytical devices using modern electronicstechniquesNanoplasmonics-based biodevicesSang Jik Kim sjick@kribb.re.krConstruction of phage displayed antibody libraryTherapeutic protein production using mammalianexpression systemsTai Hwan Ha taihwan@kribb.re.krDeveloping nanobiomaterials for biosensor applicationsSyntheses of organic materials for biodevicesRESEARCH AREASDevelopment of high-sensitivity and point-of-carebiosensorsConstructing point-of-care biosensors with high sensitivityfor applications in medical diagnoses and environmentalmonitoringDevelopment of a detection platform for harmfulchemicals in foodConstructing novel platform technologies for the detectionof harmful materials, such as small endocrine disruptingchemicals and pathogenic bacteriaBuilding highly efficient and highly sensitive biomaterialsbaseddevicesDeveloping detection devices based on the integration ofbiomaterials, such as antibodies, peptides, andoligonucleotides, with microelectronics and microfluidicdevicesDirector Min-Gon KimT + 82-42-860-4448F + 82-42-860-8594E mgkim@kribb.re.krACHIEVEMENTSDevelopment of a dual gold nanoparticle conjugate-based LFA sensorFor signal amplification without an additional operational step in a gold nanoparticle(AuNP)-based lateral flow assay (LFA), a new and simple method utilizing twoAuNPantibody conjugates was developed. The 1st conjugate was AuNP immobilized withan anti-troponin I antibody and blocked with bovine serum albumin (BSA); the 2ndconjugate was AuNP immobilized with an anti-BSA antibody and blocked with humanserum albumin. The two conjugates were encapsulated in different pads.When 10 nm of the 1st conjugate and 40 nm of the 2nd conjugate were used, detectionsensitivity increased about 100-fold compared to the conventional LFA. Levels as low as0.01 ng/mL troponin I in 10 min were detected using the dual AuNP conjugate-based LFA.Development of a palm-sized SPR sensor systemA portable surface plasmon resonance (SPR) biosensor system was developed using arotating mirror. This method eliminates image quality deterioration originating from thecoherency of the laser illumination source. A novel portable palm-sized SPR sensorsystem operated by three batteries (4.5 V) was constructed. The patent for this technologywas registered in Korea (PCT/KR2008/004701), and this technology was transferred toKoMiCo Corporation in an agreement for $3 million (USD) in royalties. This project wasachieved in collaboration with the BioNanotechnology Research Center.SELECTED PUBLICATIONSYong Beom Shin & Min-Gon Kim (Co-corresponding) Biosens Bioelectron. 25(8):1999-2002.A dual gold nanoparticle conjugate-based lateral flow assay (LFA) method for the analysisof troponinITai Hwan Ha (Corresponding) Chem Commun (Camb). 46(18):3164-6.Complete separation of triangular gold nanoplates through selective precipitation underCTAB micelles in aqueous solutionMin-Gon Kim (Co-corresponding) Langmuir. 26(14):12112-8.Addressable micropatterning of multiple proteins and cells by microscope projectionphotolithography based on a protein friendly photoresistYong Beom Shin (Corresponding) Sensors. 10(3):2045-53.Signal amplification by enzyme reaction in an immunosensor based on localized surfaceplasmon resonance (LSPR)As an inevitable consequence of a highly industrialized society, a vast multitude of chemical compounds andmicroorganisms, such as multi-drug resistant bacteria, threaten the hopes of maintaining healthy human life.The BioMonitoring Research Center attempts to build versatile and intelligent biomonitoring systems, not only forconventional food and environmental monitoring; but also for national security concerns, such biochemical terrorism.26 KRIBB Annual Report 2010KRIBB Annual Report 2010 27
KRIBB ANNUAL REPORT 2010Division ofTranslational ResearchMedical Genomics Research CenterDevelopment and Differentiation Research CenterMedical Proteomics Research CenterByoung Chul Park I DirectorTEL +82-42-860-4200 FAX +82-42-860-4269parkbc@kribb.re.krSpurring Progress in Biotreatment TechnologyOur work in pioneering fields, such as the development of biomarkers for pathogenic research in cancerand other common life-threatening diseases, and basic technology research in regenerativemedicine, harnessing the body’s own regenerative capabilities, are making significant contributions tomedical science.
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