Division of National Agenda ProjectsAI Control MaterialResearch CenterRESEARCHERSWoo Song Lee wslee@kribb.re.krIdentification of infection related target molecules andestablishment of screening systems for infection relateddiseasesIsolation and structure elucidation of active compoundsSynthesis of active compoundsMun-Chual Rho rho-m@kribb.re.krIdentification of inflammation related target moleculesand establishment of screening systems forinflammation related diseasesIsolation and structure elucidation of active compoundsYoung-Min Kim u9897854@kribb.re.krDevelopment of solubilized process of active compoundsand mass productionEnzymatic modification of infection and inflammationrelated target moleculesSu-Jin Park sjpark@kribb.re.krIsolation and bulk culture of viruses (Coronavirus,Rotavirus, Influenzavirus, etc) and genetic and phylogenicanalysis of isolated virusesPathologic, immunohistochemical, electron microscopicstudies using animalsYoung Bae Ryu ybryu@kribb.re.krIsolation and identification of secondary metabolites fromnatural resourcesIdentification of infection related target molecules andestablishment of screening systems for infection relateddiseasesRESEARCH AREASConstruction of bioassay systems related to infectiousdiseasesEstablishing bioassay and screening systems forcompounds against infectious diseases (virus, bacteriaand malaria)Developing specifically active compounds such asinhibitors of neuraminidase to combat the avian influenzavirusConstruction of bioassay systems related toinflammatory diseasesEstablishing bioassay and screening systems forcompounds against inflammatory diseases (pneumonia,asthma, arthritis, etc.)Developing specifically active compounds such asinhibitors of cell adhesion molecules, cytokines andchemokinesConstruction of a natural product fraction libraryConstructing and utilizing both a fraction from plant andmicrobial culture extracts and a natural compound libraryDirector Woo Song LeeT +82-63-570-5170F +82-63-570-5239E wslee@kribb.re.krACHIEVEMENTSIdentification of biomaterials for infectious and inflammatory diseasesInfluenza viruses bind to sialic acid on the host cell surface to initiate infection. Since sialicacids are ubiquitous, this presents two problems for the virus: (1) the virus may bind to awide variety of cells, regardless of whether the cell can support virus replication, and (2)the virus particles themselves have sialic acid incorporated into their surfaceglycoproteins, so potentially virus particles will bind to each other. Neuraminidasepromotes influenza virus release from infected cells and facilitates virus spread within therespiratory tract. And, cell adhesion molecules (ICAM-1/LFA-1, VCAM-1/VLA-4), cytokinesand chemokines, participate in cell to cell interaction that is important in the progressionof the inflammatory response in diseases such as pneumonia, asthma and others.Therefore, we have developed active biomaterials from natural resources using in vitroassay systems and related infectious and inflammatory diseases, and obtained bioactivecompounds from selected biomaterials by chromatographic techniques.Identification of new molecular targets related to infectious and inflammatory diseasesThrough research of molecular targets such as proteomics and genomics, new targetcandidates of inflammatory and viral infectious diseases have been identified. Weestablished assay/screening systems for inflammation and virus related diseases.In vitro and in vivo antiviral evaluationsWe established the identification of cultures and quantitative titration methods for severalviruses including the influenza virus, rotavirus, coranvirus, rhinovirus and enterovirus, anddeveloped new active biomaterials and immunotherapies against viruses, utilizing virology,mechanisms of action, in vitro activity and animal models.Natural product fraction libraryTo compile a natural product fraction library, we are collecting plant resources andutilizing plant extracts through open column chromatography and a natural productlibrary.SELECTED PUBLICATIONSSu-Jin Park & Woo Song Lee (Co-corresponding) Bioorg Med Chem. 18(21):7668-74.In vitro anti-rotavirus activity of polyphenol compounds isolated from the roots ofGlycyrrhiza uralensisMun-Chual Rho & Woo Song Lee (Co-corresponding) Bioorg Med Chem. 18(22):7940-7.Bisflavonoids from Torreya nucifera displaying SARS-CoV 3CL pro inhibitionMun-Chual Rho & Woo Song Lee (Co-corresponding) Bioorg Med Chem Lett. 20(6):1873-6.SARS-CoV 3CL pro inhibitory effects of quinone-methide triterpenes from TripterygiumregeliiSu-Jin Park (Co-corresponding) Vet Microbiol. 144(3-4):274-86.Detection and genotyping of Korean porcine rotavirusesOur aim is to develop functional foods, natural feeds and therapeutic materials against infectious diseases (virus, bacteria andmalaria) and inflammatory diseases (pneumonia, asthma, arthritis, etc.) from the natural product library, startingwith traditional medicines.86 KRIBB Annual Report 2010KRIBB Annual Report 2010 87
KRIBB ANNUAL REPORT 2010BiotechnologyR&D InfrastructureKorean Bioinformation CenterWorld Class InstituteInternational Biological Material Research CenterDAEJEON-KRIBB-FHCRC Research Cooperation CenterBiotech Policy Research CenterKorea Biosafety Clearing HouseMicrobial Genomics & Applications CenterSharing Biotech Value by Expanding Bio-Infrastructureand Providing Information SupportTo enhance the public biosafety awareness, contribute to the growth of the bioindustry and extend the benefitsof biotechnology to broader segments of society, KRIBB supplies the latest information on biotech policies inKorea and worldwide through its information-sharing network. KRIBB also procures biomaterials not availablein Korea, from overseas resources, and distributes them to industry and academia.
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