Untitled

Biotechnology R&D InfrastructureMicrobial Genomics &Applications CenterRESEARCHERSTae Kwang Oh otk@kribb.re.krMicrobial EnzymologyDirector of Microbial Genomics and Applications CenterJiHyun F Kim jfk@kribb.re.krMicrobial GenomicsBacteria-host interactionJung Hoon Yoon jhyoon@kribb.re.krBiodiversityMetagenomeMyung Hee Kim mhk8n@kribb.re.krProtein structure and functionMacromolecular crystallographyMechanism of signaling by histidine kinaseRESEARCH AREASMicrobial diversity and metagenomesScreening of extremophiles and interaction microbesDevelopment of isolation and screening techniques foruncultivated microbesScreening of goal-directed and beneficial microbesMetagenome analysis and beneficial gene screeningAnalysis of viral metagenomes and development ofbeneficial genesIntegrated functional analysis of microbial genomesGenomic network of model systemsRegulatory network of interactive microbesApplications of microbial interactionsRedesign of metabolic circuitsMicrobial technological convergenceFuture technologies for bioenergyMicrobial protein structure and functionIndustrial application of microbial genomesDevelopment of fermentation and bioprocessingtechnologies based on cell reengineeringDevelopment of highly functional enzymeInvestigation of novel physiological active materialsPlatform biomaterial development suitable for genomereengineeringSynthetic biology-based novel biomaterial developmentIdentification of novel enzyme and development ofapplication technologyInfrastructureMicrobial Genome InfoBase / www.gem.re.krMicrobial Resources Bank / www.microbank.re.krProtein Bank / www.pbsb.re.krDirector Tae Kwang OhT + 82-42-879-8200F + 82-42-879-8209E otk@kribb.re.krACHIEVEMENTSWe developed highly efficient Xylitol production process by genomic reconstruction inCandida tropicalis (KAIST) and developed Corynebacterium glutamicum amino acidproducing strain and bioprocess for low cost /high yields /high productivity using Genomebasedcell reconstruction technology (CJ Co., Ltd), and developed the production methodfor a novel xylitol dehydrogenase and L-xylulose using the some enzyme. (Konkuk Univ.)We unveiled the early stage of bacterial genome-reductive evolution in the host (KoreaUniv.) for the first time (publically available through PLOS Patohgens) and it may representthe key component of a general mechanism for early bacterial evolution in the host.We developed the cell-free expression method of Membrane domain structures and rapidNMR analysis (publically available through Proceedings of the National Academy ofSciences) at the Korea Basic Science Institute.We aim to promote the discovery of novel genes, valuable biomolecules, engineered microbes and innovative bioprocesses.The Microbial Genomics and Applications Center focuses on developing technology platforms to utilize information aboutgenome function obtained from analyses of microbial genomes isolated from diverse environments.To elevate Korea to one of the top countries in the world microbial industryTo create a market exceeding a billion dollarsTo construct global knowledge infrastructure by acquiring key intellectual property rights102 KRIBB Annual Report 2010KRIBB Annual Report 2010103