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Korea Biological Resource CenterACHIEVEMENTSAnimal ModelResource CenterAnimal model establishment and research supports for animal experimentsWe have established 3 mouse models for human disease research as transgenic andknockout strains, and supported 84 cases of IACUC-approved animal experiment, 19cases of pathological experiment, and 30 cases of hematological and biochemicalanalyses. Also, we have performed (4 times) educational service associated with animalethics and appropriate animal experiments for animal experimenters and periodicalhealth monitorings (4 times) of animals being maintained for the prevention of diseasetransmission.RESEARCHERSChul-Ho Lee chullee@kribb.re.krDevelopment of animal models for human metabolicdiseaseDiscovery and validation of functional genes associatedwith metabolic diseaseByung-Hwa Hyun hyunbh@kribb.re.krGenetic study of animal models for human neurologicaldiseasesDevelopment of animal models with non-humanprimatesRESEARCH AREASDevelopment and establishment of animal models forhuman diseases by using transgenic, knock-out andselective breeding techniquesResearch supports for animal experiments, veterinarycare, and pathological, hematological and biochemicalanalyses using animal model resourcesFunctional validation of the genes associated withhuman diseasesTechnical supports for the disease model production andmaintenanceDirector Chul Ho LeeT + 82-42-860-4637F + 82-42-860-4609E chullee@kribb.re.krRESEARCH ACTIVITIESIn 2010, we published 17 papers concerning metabolic diseases (arising from ourresearch using disease animal model resources) and registered 2 patents.Also, we contributed 29 papers for publications resulting from KRIBB research into animalexperiment support; including animal husbandry and pathological, hematological andbiochemical analyses.SELECTED PUBLICATIONSChul-Ho Lee (Corresponding) Food Chem Toxicol. 48(11):3177-83.Antioxidant effects of the chestnut (Castanea crenata) inner shell extract in t-BHP-treatedHepG2 cells, and CCl 4- and high-fat diet-treated miceJung Hwan Hwang coccs99@kribb.re.krPhenotyping and development of genetically alteredanimal modelsGenetic quality control of animal modelsYong-Hoon Kim milknut@kribb.re.krSupports for veterinary care and histopathologicalanalysisMicrobiological and environmental quality control ofanimal modelsChul-Ho Lee (Corresponding) Food Chem. 121(2):437-42.Chestnut (Castanea crenata) inner shell extract inhibits development of hepatic steatosisin C57BL/6 mice fed a high-fat dietByung-Hwa Hyun (Co-corresponding) In Vitro Cell Dev Biol Anim. 46(2):148-54.The effects of various antioxidants on the development of parthenogenetic porcine embryosByung-Hwa Hyun (Co-corresponding) J Biol Chem. 285(37):28627-34.Effects of regulator of G protein signaling 19 (RGS19) on heart development and functionChul-Ho Lee (Corresponding) Life Sci. 87(13-14):405-10.Differential modulatory effects of rosiglitazone and pioglitazone on white adipose tissue indb/db miceThe goal of our center is to establish an infrastructure for animal experiments and to generate animal models for humandiseases by mutagenesis (such as transgenic, gene targeting and natural breeding) for in vivo validation of genesassociated with human diseases.52 KRIBB Annual Report 2010KRIBB Annual Report 2010 53