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Division of Translational ResearchMedical ProteomicsResearch CenterRESEARCHERSByoung Chul Park parkbc@kribb.re.krTarget mining and validation using proteomicsSignal transductionSang Chul Lee lesach@kribb.re.krDiscovery of novel biomarkers using proteomic analysisStem cell differentiationSung Goo Park sgpark@kribb.re.krMechanism and functions of apoptosis-related proteinsProtease degradomicsSeung Jun Kim ksj@kribb.re.krStructural studies on anti-oxidant proteins and proteintyrosine phosphatasesDrug development using 3-D structural informationSeung-Wook Chi swchi@kribb.re.krAntiapoptotic drug development using NMR studiesFunctional studies on apoptosis-related proteinsKwang-Hee Bae khbae@kribb.re.krTarget mining and validation using proteomics andreverse genetics toolsStudies on proteins involved in stem cell differentiationand neurodegenerative diseasesEui-Jeon Woo ejwoo@kribb.re.krStructural and functional studies on DNase and proteinsin apoptosisHormone nuclear receptors and their applicationSunghyun Kang skang@kribb.re.krAptamersProteomics and Mass spectrometryDae Gwin Jeong dgjeong@kribb.re.krStructural proteomics, Virtual screening for leadcompoundsJeong Hee Moon jhdal@kribb.re.krMass spectrometryTae-Sung Yoon yoonts@kribb.re.krStructural proteomics, X-ray crystallographyJeong Hoon Kim jhoonkim@kribb.re.krEpigenetics, Transcription regulationRESEARCH AREASAutoimmune disordersDiscovery and functional verifications of biomarkersfrom patients suffering from immune diseases, e.g.atopic dermatitis, asthma, and rheumatoid arthritisApoptosisIdentification and functional studies on new substrates ofcaspases, key regulators of apoptosisNeuroscience and neurodegenerative diseasesProteomic research on neuronal cell functions andneurodegenerative diseasesDifferentiation of stem cellsDiscovery and functional verification of genes andmarker proteins, which are involved in the differentiationof stem cells into various lineages including adipocytesand osteoblastsCell signalingResearch on the mechanisms of key cell signalingpathways, e.g. MAPK and NF-kB pathwaysResearch on structures and functionsAscertainment of structures, based on X-raycrystallography and NMR, which will lead to findingsconcerning the unique functions and mechanisms ofvarious proteins (such as protein tyrosine phosphatasesand hormone receptors) with medical and industrialimportanceDirector Byoung Chul ParkT + 82-42-860-4200F + 82-42-860-4269E parkbc@kribb.re.krACHIEVEMENTSProteomic research on neuronal cell deathProteomic research led to the discovery of key proteins involved in the apoptosis ofneuronal cells. Functional studies of these proteins were conducted.Research on apoptosis and cell signalingProteomic research led to the discovery of regulators of cellular apoptosis and cellsignaling. The results were published in major scientific journals.Structural studies on human protein tyrosine phosphatases (PTPs)Efforts to determine the complete PTP structure and broadening our understanding of thefunctions of human PTPs.SELECTED PUBLICATIONSEui-Jeon Woo (Corresponding) Analyst. 135(11):2879-86.Development of a nanoparticle-based FRET sensor for ultrasensitive detection ofphytoestrogen compoundsSung Goo Park & Kwang-Hee Bae (Co-corresponding) Cell Mol Life Sci. 67(13):2271-81.Annexin A4 interacts with the NF-kappaB p50 subunit and modulates NF-kappaBtranscriptional activity in a Ca 2+ -dependent mannerByoung Chul Park (Co-first) Cell Mol Life Sci. 67(15):2619-29.Positive regulation of apoptosis signal-regulating kinase 1 by dual-specificityphosphatase 13ASeung Jun Kim (Co-corresponding) FASEB J. 24(2):560-9.Crystal structure of ED-Eya2: insight into dual roles as a protein tyrosine phosphatase anda transcription factorEui-Jeon Woo (Co-corresponding) J Mol Biol. 404(2):247-59.Structural insights on the new mechanism of trehalose synthesis by trehalose synthaseTreT from Pyrococcus horikoshiiWe will become the R&D hub of nationwide translational research in Korea using functional and structural proteomics as aresearch tool. We are establishing close collaborations with many partner groups in basic research and clinical medicine. Ourmajor research interests include autoimmune disorders, apoptosis, neurodegenerative diseases, stem cell differentiation, andcell signaling.34 KRIBB Annual Report 2010KRIBB Annual Report 2010 35
KRIBB ANNUAL REPORT 2010Division ofBiosystems ResearchIndustrial Biotechnology & Bioenergy Research CenterPlant Systems Engineering Research CenterIndustrial Bio-materials Research CenterEnvironmental Biotechnology Research CenterHee-Mock Oh I DirectorTEL +82-42-860-4321 FAX +82-42-879-8103heemock@kribb.re.krA More Prosperous FutureSolving critical problems facing our planet and maximizing our natural resources for a sustainablefuture is an important area of activity at KRIBB. Unveiling the hidden properties of plants, microorganismsand insects and using them to brew new biomaterials; basic bioenergy technology research;and extracting industrial materials from bioresources are some examples of our endeavors in this area.
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