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Biotechnology R&D InfrastructureKoreanBioinformation CenterRESEARCH AREASExpression and Regulation TeamDevelopment of analysis pipelines and core algorithms for RNA-sequencingConstruction of analysis pipelines for epigenome and small RNA dataBiomedical Informatics TeamDevelopment of databases and systems for microarray data analysisDevelopment of integrated analysis systems for cancer genome dataRESEARCHERSSanghyuk Lee sanghyuk@kribb.re.krBioinformatics of genome and proteomeAlternative splicing and microRNAByungwook Lee bulee@kribb.re.krProcessing NGS datagene expression analysis and epigenomic regulationIn-Sun Chu chu@kribb.re.krBiomedical informaticsSystems cancer biologyBoKyeng Hou bkher71@kribb.re.krDevelopment of Korean Bio-resource Information System(KOBIS)Systems biology and chemoinformaticsNamshin Kim deepreds@kribb.re.krDe novo assembly and integrative analysis of genomesGenome mutation analysis with expression, phenotype,and diseaseGenome variation analysis and their evolutionary studiesGenomics research via comparative genomics approachesSeungwoo Hwang swhwang@kribb.re.krGene expression data analysis and knowledge discoverySystems biology through network approachJinhyuk Lee jinhyuk@kribb.re.krProtein structure modeling.Chemo-informatics research.Kyung Mo Kim kmkim@kribb.re.krEvolution of proteomes, functomes, and metabolomesPhylogenomics of transcriptomes for ontogeneticdivergenceChangsik Kim cskim70@kribb.re.krModeling signal pathways and gene regulatory networkMachine learning and computational statistics withapplication to molecular biologyComputational systems biology approach in cancer biologyDongsoo Jung dsjung@kribb.re.krPlanning for KOBIC's web servicesKOBIC website management and maintanceTae-Kyung Kim tkkim@kribb.re.krDevelopment of Korean Bio-Resource Information SystemText MiningBio-Cloud ComputingNGS Data Compression and DeliverySangcheol Kim sckim@kribb.re.krStatistical analysis of the DNA microarray experimentStatistical analysis of the NGS experimentMultivariate analysisJinah Park jinah@kribb.re.krManual curation and interpretation of bioinformatics dataExpression signature for metastasisRESEARCH AREASGenome Informatics TeamDe novo assembly and integrative analysis of genomesGenome mutation analysis with regard to expression,phenotypes, and diseasesGenome variation analysis and their evolutionary studiesGenomics research via comparative genomics approachesDirector Sanghyuk LeeT + 82-42-860-8500F + 82-42-860-8519E sanghyuk@kribb.re.krSystems Bioinformatics TeamIntegration of biological networks and annotation of informationDevelopment of algorithms, tools, and DBs for systems bioinformaticsStructural Informatics TeamProtein structure modeling (homology modeling)Structure determination with experimental observables (NMR, X-ray)Development of algorithms, tools, and DBs for structural informaticsBioresource Information TeamConstruction of an integrated information system for national bioresourcesDevelopment of national data standardsBuilding national collaborations and liaison networksInformation Service TeamImprovement and preservation of web-service systemDevelopment of service itemComputer System TeamDevelopment and management of servers, clusters, and storage systemsSupport for developing web-based solutionsImplementation of CLOUD computing infrastructureACHIEVEMENTSIn an effort to support bioinformatics and genomics research in Korea, we developnumerous bioinformatics algorithms and applications, with emphases on (i) NextGeneration Sequencing (NGS), (ii) systems bioinformatics, (iii) biomedical informatics, and(iv) structural informatics. The resulting pipelines and knowledgebases are provided tobiologists and bioinformaticians to facilitate biological interpretation of OMICS data,especially the large-scale genomics data. In addition, we actively participate in manyinternational collaborative projects for research and education.SELECTED PUBLICATIONSByungwook Lee (Corresponding) BMC Genomics. 11(Suppl 4):S20.Gerontome: a web-based database server for aging-related genes and analysis pipelinesIn-Sun Chu (Co-corresponding) Hum Mutat. 31(8):942-9.Short rare MUC6 minisatellites-5 alleles influence susceptibility to gastric carcinoma byregulating geneThe Korean Bioinformation Center (KOBIC) is the national research center for bioinformatics which plays a key role in variousareas such as genomics, proteomics, systems biology, and personalized medicine. KOBIC is also responsible for the integrationand management of bioresource and biodiversity information from various research labs and institutions across the country.KOBIC provides a centralized data access portal to promote data sharing and utilization among research groups.In-Sun Chu (Corresponding) J Clin Oncol. 28(16):2660-7.Expression signature of E2F1 and its associated genes predict superficial to invasiveprogression of bladder tumors90 KRIBB Annual Report 2010KRIBB Annual Report 2010 91
Biotechnology R&D InfrastructureWorld Class Institute(WCI)ACHIEVEMENTSHuman whole gene siRNA screening for discovery of cancer markerHuman whole gene siRNA screening for discovery of N-degron associated genesChemical biology for target identification and drug designComputational biology for HTSGeneration of xenograft mouse modelRESEARCHERSRaymond Erikson erikson@fas.harvard.eduDirector of WCI Center for Kinomics-based AnticancerResearchRESEARCH AREASGene and protein identification for cancer controlBreast cancer, skin cancer, hepatic cancer, prostatecancer and cervical CancerDirector Raymond EriksonT + 82-43-240-8250F + 82-43-240-6169E erikson@fas.harvard.eduOsteoclast differentiation and cancerBo Yeon Kim bykim@kribb.re.kr, kimbotaekim@gmail.comDeputy Director of WCI Center for Kinomics-basedAnticancer ResearchDiscovery of new anticancer drug candidatesMedicinal plants, micobial secondary metabolites,chemical librariesDae Yeol Yu dyyu10@kribb.re.krDisease Model. WCI Korean ResearcherProtein degradation in association with diseaseN-end rule pathway, endoplasmic reticulum stressSeung Jun Kim ksj@kribb.re.krStructural Biology. WCI Korean ResearcherEpigenomic DNA regulationCell division, DNA methylation and metastasisSunhong Kim sunhong@kribb.re.krMolecular Cancer Biology. WCI Korean ResearcherChemical BiologyProtein target identification and in vivo, ex vivo applicationNak-Kyun Soung soungnak@kribb.re.krCell Division. WCI Visiting ResearcherHyunjoo Cha-Molstad hcha@kribb.re.kr, chamolstad@hotmail.comWCI International ResearcherKangdong Liu kdliu@kribb.re.krWCI International ResearcherKrisada Sakchaisri sakchaik@kribb.re.krWCI International ResearcherHaidan Liu haidan@kribb.re.kr, lhd1129@126.comWCI International ResearcherThimmegowda N.R. nrtgowda@kribb.re.kr, nrthimmegowda@gmail.comWCI International ResearcherJoon Sung Hwang hwangj1@mail.nih.govWCI International ResearcherWCI is composed of eight international researchers, eight Korean researchers and eight international collaborators. Until now,five postdoc fellow and Ph.D students are working at each collaborator's institutions. The aim of WCI is to discover four anticancertargets and therapeutic drug candidates. Each of the four groups - Cell and Molecular Biology Team, Structural Biology Team,Xenograft Animal Model Team and Chemical Biology Team is closely collaborating each other with their results. Director Dr.Raymond Leo Erikson from Harvard University leads and organizes most of the researches and global networks. After five yearsof the WCI program, this center will be one of the world-leading groups in cancer biology and cancer therapeutics development.92 KRIBB Annual Report 2010KRIBB Annual Report 2010 93
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