A COMPENDIUM OF DRUGS USED FOR LABORATORY ANIMAL ...

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Swine 2 Sedate with midazolam 0.5 mg/kg IM. 146 Propofol 2.5mg/kg IV until no reflexes. Intubate and respirate withO 2 /NO (50:50) at 150 ml/kg/min. Then alpha chloralose100 mg/kg IV. 146Swine 3 Sedate with ketamine:xylazine (q.v.). Propofol 4-8mg/kg/hour (mix two 20 ml vials of 10 mg/kg propofol in500 ml bag of dextrose (5% in water).Dosage frequencyBird 2-7 minutes 136Cat 10 minutes 37Dog 1 15 minutes 220Mouse 1 6-7 minutes 132 , 5-10 minutes 177Primate 4 20 minutes 282Rabbit 2 5-10 minutes 177Rabbit 5 4-16 minutes 132Rat 1 6-11 minutes 217Sheep 1 5-10 minutes 135CommentsAllMust be given IV. Poor analgesic.Bird Respiratory depression 136Dog 1-4 May cause bradycardia. 23 Not recommended forGrehounds 113Rabbit 1See also, metdetomidine and midazolam. Forimmobilization only.Rabbit 1-4Apnea at surgical levels if used as sole anesthetic. Usewith analgesics, intubate and ventilate. Consider this drugto be a hypnotic 158Reptile 1 Can lead to prolonged anesthesia 280PROPOXYPHENE (Darvon, Dolene)Class Analgesic. Controlled substance.Source Lilly, genericRat 25 mg/kg IP 81CommentsAllMild analgesiaPYRIDOSTIGMINE (Mestinon)Class Nondepolarizing neuromuscular blocking agent antagonistSource ICN PharmaceuticalsDog 0.2-0.3 mg/kg IV 50
Dosage frequencyDog 15 minutes 50CommentsDogGive slowly over 5 minutes. Dilute dose in 10 ml ofsaline 50Precede with atropine 0.04 mg/kg IV, given slowly 57ROCURONIUM (Zemuron)Class Nondepolarizing skeletal muscle relaxantSource OrganonCat 0.16-0.3 mg/kg IV 216Swine 0.7 mg/kg IV (ED 50 ) 216Dosage frequencyCat 7 minutes 216Swine 10 minutes 216AntagonistEdrophonium (q.v.)Neostigmine (q.v.)ROMIFIDINE (Sedivet)Class Alpha-3 agonistSource Boehringer Ingelheim (Canada). Not available in USCat 0.04 mg/kg IM with butorphanol 0.4 mg/kg IM 277Dog 0.04 mg/kg IM with butorphanol 0.4 mg/kg IM 277Sheep 1 50 mg/kg IV 135Sheep 2 0.05 mg/kg IV 221CommentsSheep 1It is possible that the author meant micrograms/kg, notmilligrams/kg.SEV<strong>OF</strong>LURANE (Ultane)Class AnestheticSource AbbottCalf 4-5% mask induction. Maintain at 2.5%Dog 3.0% in oxygen flow of 3 liters/min 194Goat 4-5% mask induction. Maintain at 2.5%Mouse Do not use. “Difficult induction” 172RatDo not use. See comments.
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A COMPENDIUM OF DRUGS USED FOR LABO
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SIGNS OF PAIN IN ANIMALSThe pain th
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Proposed Method to Quantify Pain, D
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needle is often used. To help preve
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GENERAL REQUIREMENTS FOR SURVIVAL S
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DETAILED CONSIDERATIONS FOR ANIMAL,
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SURGICAL SCRUB FOR THE SURGEONA. An
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RULES OF THUMB FOR ASSESSING THE NE
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Reptile:Sheep/Goat:Swine:meperidine
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ANALGESIA (8 OR MORE HOURS DURATION
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Reptiles:Sheep/Goat:Swine:ketaminea
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NEUROMUSCULAR BLOCKING/IMMOBILIZING
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fentanyl/droperidol, fentanyl/fluan
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A COMPENDIUM OF DRUGS USED FOR LABO
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Rabbit 3 0.1-0.2 mg/kg IV 21Rat 1 1
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ClassSourceNondepolarizing neuromus
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Rabbit 1 5-10 minutes 177Rabbit 2 8
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ClassSourceButyrophenone tranquiliz
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See commentsRabbit 50.5 mg/kg per r
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Rabbit 31.0 mg/kg SC, IM with acepr
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Bird 1-4 mg/kg IM 277Cat 1 2-4 mg/k
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Rat 12 hours 21 , 65 minutes (300 g
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Frog 30 mg/kg in dorsal lymph sac 2
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As long as gas is providedAntagonis
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Rabbit 11.0 mg/kg IM, IP 28 See com
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Cat 10.1-0.2 mg/kg IVCat 2 0.25-0.5
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Dosage frequencyDog 1, 25-10 minute
Page 55 and 56: Cat 4 5.0-10.0 µg/kg epidural 277D
Page 57 and 58: Dog 1 30 minutes 220Dog 3 2 hours 6
Page 59 and 60: Gerbil 1 20-30 minutes 177Gerbil 2
Page 61 and 62: Guinea Pig76, 17512-24 hoursHamster
Page 63 and 64: Dosage frequencyAs long as gas is s
Page 65 and 66: Rabbit 2 6-8 hours 269Rat 1 4 hours
Page 67 and 68: Bird 110-30 mg/kg IM with xylazine,
Page 69 and 70: Guinea Pig 12 44 mg/kg IM with acet
Page 71 and 72: Rabbit 14 Diazepam 0.2-0.5 mg/kg IV
Page 73 and 74: Sheep 12Sheep 131.5 mg/ml ketamine,
Page 75 and 76: Swine 1 30 minutes 221Swine 2 20 mi
Page 77 and 78: Dog 2142, 277Once a day for 5 daysF
Page 79 and 80: All species Topical on skin 15 minu
Page 81 and 82: Sheep 3 0.005 mg/kg IV 221Sheep 3 0
Page 83 and 84: Goat 1 Up to 200 mg/kg IM total dos
Page 85 and 86: Dog 2 0.7-1.0 mg/kg epidural 277Dog
Page 87 and 88: DogOften use flow rate of 15 ml/min
Page 89 and 90: MIVACURIUM (Mivacrom)Class Nondepol
Page 91 and 92: Guinea Pig 1 2-3 hours 5, 10 , 4 ho
Page 93 and 94: Primate 2 6 hours 76Rabbit 1 4-5 ho
Page 95 and 96: Dosage frequencyDog Every 24 hours
Page 97 and 98: Primate 1, 21, 2193-6 hoursRabbit 3
Page 99 and 100: Cat 3 6 hours 121Dog 1 4 hours 12 ,
Page 101 and 102: Cat 115-30 minutesCat 3 6 hours 72D
Page 103 and 104: Dog 1 8 hours 20Dog 1 up to 7 days
Page 105: Dog 1 0.11 mg/kg IV 178Dog 2See Met
Page 109 and 110: Cat 1, 2 Subsequent doses are ½ or
Page 111 and 112: Rat 1 30 mg/kg IV of 1.25% solution
Page 113 and 114: Swine 22.2 mg/kg IM with xylazine,
Page 115 and 116: ClassSourceAnestheticAldrich, Pfalt
Page 117 and 118: Swine 1 10 minutes 216 4 minutes 21
Page 119 and 120: CommentsCalf Will cause hyperglycem
Page 121 and 122: References1. Bacher, J. Primate Ane
Page 123 and 124: 29. Product insert for Ketaset (For
Page 125 and 126: 65. Silverman, J., Huhndorf, M., Ba
Page 127 and 128: 98. Malm, T., Bowald, S., Bylock, A
Page 129 and 130: 129. Vainio, O. and Ofala, M. Medet
Page 131 and 132: 172. Whelan, G. CompMed e-mail disc
Page 133 and 134: 211. J. Silverman, Clinical experie
Page 135 and 136: 250. Cooper, D. CompMed e-mail disc
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A COMPENDIUM OF DRUGS USED FOR LABORATORY ANIMAL ...

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