A COMPENDIUM OF DRUGS USED FOR LABORATORY ANIMAL ...

ClassSourceAnestheticAldrich, Pfaltz & Bauer, other chemical suppliersGerbil 1 250-300 mg/kg IP of 1.25% solution 37Gerbil 2 225-250 mg/kg SC of 2.25% solution IP. 132 Anesthesia.Sedation 132Mouse 12, 37125 mg/kg IP of 0.25% solutionMouse 2 250 mg/kg IP 28, 66 Surgical anesthesiaMouse 30.015-0.017 ml/gram IP of following: Make stock solutionby mixing 10 ml of tertiary amyl alcohol with 10 gramstribromoethanol. Take 1.25 ml of stock solution and add to48.75 ml of water or saline (i.e. a 2.5% solution). Filtersterilize and place in sterile bottle. Store in foil, inrefrigerator 95 up to 6 weeks.Mouse 4 450 mg/kg IP as a 2.5% solution 277Rat2, 37300 mg/kg IPDosage frequencyGerbil 1 10-35 minutes 132Gerbil 2 20-63 minutes 132Mouse 1 15-20 minutes 2Mouse 215-45 minutesRat 15-20 minutes 2CommentsAll Must be carefully prepared as in reference 66AllGood muscle relaxationRat High mortality possible 37 Fibrous adhesions andperitonitis at 200-400 mg/kg. Hepatic capsular fibrosis andadhesions. 241Mouse 1, 2 High mortality possible 37 May cause peritonitis andfibrinous seroisitis of abdominal organs 227Mouse 2 Varies from deep to light anesthesia 95URETHANE (ethyl carbamate, 50% w/v).Class AnestheticSource Sigma Chemical, Aldrich ChemicalAmphibian 1 1.0-2.0% solution 148Amphibian 2Cat 1250 mg/kg IV 37Dog 1000 mg/kg IV 37Ferret 1500 mg/kg IP 116Fish 5.0-40 mg/liter 148Guinea Pig2, 371500 mg/kg IV, IPFrog? 0.04-0.12 ml/gram of 5.0% solution into dorsallymph sac 148