A COMPENDIUM OF DRUGS USED FOR LABORATORY ANIMAL ...

Dosage frequencyAs long as gas is suppliedAntagonistOxygen (not a true antagonist)CommentsAllExplosive.AllRespiratory tract irritant.AllCan cause cardiac arrest at high concentrations.All Stimulates catecholamine release 37RabbitCan cause laryngospasm. Hold breath and may havecardiac depression 80ETHYLISOBUTRAZINE (Diquel)Class Phenothiazine tranquilizerSource CoopersDog 1 4.4-11 mg/kg IM, PO 72Dog 2 2.2-4.4 mg/kg IV 72Swine 1 1.25 mg/kg IV 222Swine 2 2.2-4.4 mg/kg IM 222Dosage frequencyDog 1 6-72 hours. Dose dependent 72ETOMIDATE (Amidate, Hypnomidate)Class Non-barbiturate hypnoticSource Abbott. Not available in U.S.Cat 1.1-4.4 mg/kg IV 21 See Comments.Dog 1 1.1-4.4 mg/kg IV 21Dog 2See “Medetomidine”Fish 1 Channel catfish: 2-10 mg/liter (anesthesia) 123Fish 2 Tropical. 2-10 mg/liter (anesthesia) 123Guinea Pig 0.14 mg/kg IV 28Mouse 1 24-30 mg/kg IP 28, 85, 132 . Anesthesia 82Mouse 2 11.2 mg/kg IV 132Primate 0.5-2.0 mg/kg IV 282 Anesthesia induction.Rabbit 1.1-4.4 mg/kg IV 21Rat 0.57-1.11 mg/kg IV 28Sheep 2.0 mg/kg IV 221 Anesthesia.Swine 1 1.1-4.4 mg/kg IV 21Swine 24.0-8.0 mg/kg IV 221 . See azaperoneSwine 30.6 mg/kg IV with ketamine infusion of 10 mg/kg/hr IV.Anesthesia 240