A COMPENDIUM OF DRUGS USED FOR LABORATORY ANIMAL ...

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Dog 3 8.8 mg/kg IV with opioid premedication 72Mouse 25-50 mg/kg IV 20Primate 25 mg/kg IV 148Rabbit 15-25 mg/kg of 1% solution, IV 5Rat 20-50 mg/kg IV 20Sheep 13.2 mg/kg IV 72Swine 1 6.6-8.8 mg/kg IV 3Swine 2 9-13 mg/kg IV 21Swine 317.6 mg/kg IV 72 (from package insert)Dosage frequencyDog 1 15 minutes 6Sheep 4-12 minutes 72Swine 2 15 minutes 6 , 5-10 minutes 37CommentsAllSome species (e.g. cats) may have transient apnea duringinductionTHIOPENTAL (Pentothal)Class Thiobarbiturate anesthetic. Controlled substance.Source AbbottCalf 1 9-13 mg/kg IV 21Calf 2 25 mg/kg IV 221Cat 1 16-25 mg/kg IV 6Cat 2 9-13 mg/kg IV 21Dog 1 16-25 mg/kg IV 6Dog 2 5-10 mg/kg IV 111Dog 3 9-13 mg/kg IV 21Gerbil 40 mg/kg IP 119Goat 1 10-15 mg/kg IV 37Goat 2 25 mg/kg IV 221Guinea Pig 1 20 mg/kg IV 20 IP 175Guinea Pig 2 55 mg/kg IP 28Hamster 1 20 mg/kg IV 20Hamster 2 20-40 mg/kg IP 119Mouse 130-40 mg/kg IV 2 surgical anesthesiaMouse 2 50 mg/kg IP 28Primate 1 15-20 mg/kg IV 37Primate 2Ketamine 5.0 mg/kg IM then thiopental at 8.0 mg/kg/hourIV 183Primate 3Baboon 15-17 mg/kg/hr IV drip. 219 Anesthesia induction.Rabbit 1 50 mg/kg IV 28Rabbit 2 28 mg/kg IV, IP 148Rabbit 3 15-25 mg/kg of 1% solution, IV 5
Rat 1 30 mg/kg IV of 1.25% solution 37Rat 2 40 mg/kg IP 28Sheep 1 10-15 mg/kg IV 37Sheep 2 4.0 mg/kg IV in 2.5% solution. Drip at 50-75 mg/min 124Sheep 3 25 mg/kg IV 221Swine 16.6-8.8 mg/kg IVSwine 2 3.0-30 mg/kg/hr IV infusion 240 50-75 μg/kg/min IVinfusion 3Swine 3See MidazolamSwine 4 24-30 mg/kg IV 148Dosage frequencyCat 1 15 minutes 6Dog 1 15 minutes 6Dog 1 5-10 minutes 37Dog 2, 3 15 minutes 220Goat 5-10 minutes 37Mouse 1 10 minutes 132Primate 1 5-10 minutes 37Rabbit 1, 3 5 minutes 177Rat 1 5-10 minutes 37Sheep 1 5-10 minutes 37CommentsAllAllRabbitSome species (e.g. cats) may have transient apnea duringinductionAdminister first 1/3 rapidly to avoid excitement phase ofanesthesiaDilute 1:10 with salineTILETAMINE (Combined with zolazepam as Telazol)Class Arylcycohexylamine dissociative anesthetic with benzodiazepinetranquilizer. Controlled substance.Source Fort Dodge, RobinsCalf 14.0 mg/kg IV 135 anesthesiaCalf 2 4.0 mg/kg IV with xylazine 0.1 mg/kg IM 135Cat 1 1.0 mg/kg IV 133Cat 2 5.0 mg/kg SC, IM 133Cat 3 2.0-15.0 mg/kg IV, IM 58Dog 1 1.0 mg/kg IV 133Dog 2 2.0-13.0 mg/kg IV, IM 158Dog 3 5.0 mg/kg IM, SC 133Ferret 1 12-22 mg/kg IM, SC 130 Minor surgery. 136Ferret 2 Not recommended at 22 mg/kg IM 185
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A COMPENDIUM OF DRUGS USED FOR LABO
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SIGNS OF PAIN IN ANIMALSThe pain th
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Proposed Method to Quantify Pain, D
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needle is often used. To help preve
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GENERAL REQUIREMENTS FOR SURVIVAL S
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DETAILED CONSIDERATIONS FOR ANIMAL,
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SURGICAL SCRUB FOR THE SURGEONA. An
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RULES OF THUMB FOR ASSESSING THE NE
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Reptile:Sheep/Goat:Swine:meperidine
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ANALGESIA (8 OR MORE HOURS DURATION
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Reptiles:Sheep/Goat:Swine:ketaminea
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NEUROMUSCULAR BLOCKING/IMMOBILIZING
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fentanyl/droperidol, fentanyl/fluan
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A COMPENDIUM OF DRUGS USED FOR LABO
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Rabbit 3 0.1-0.2 mg/kg IV 21Rat 1 1
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ClassSourceNondepolarizing neuromus
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Rabbit 1 5-10 minutes 177Rabbit 2 8
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ClassSourceButyrophenone tranquiliz
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See commentsRabbit 50.5 mg/kg per r
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Rabbit 31.0 mg/kg SC, IM with acepr
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Bird 1-4 mg/kg IM 277Cat 1 2-4 mg/k
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Rat 12 hours 21 , 65 minutes (300 g
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Frog 30 mg/kg in dorsal lymph sac 2
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As long as gas is providedAntagonis
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Rabbit 11.0 mg/kg IM, IP 28 See com
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Cat 10.1-0.2 mg/kg IVCat 2 0.25-0.5
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Dosage frequencyDog 1, 25-10 minute
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Cat 4 5.0-10.0 µg/kg epidural 277D
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Dog 1 30 minutes 220Dog 3 2 hours 6
Page 59 and 60: Gerbil 1 20-30 minutes 177Gerbil 2
Page 61 and 62: Guinea Pig76, 17512-24 hoursHamster
Page 63 and 64: Dosage frequencyAs long as gas is s
Page 65 and 66: Rabbit 2 6-8 hours 269Rat 1 4 hours
Page 67 and 68: Bird 110-30 mg/kg IM with xylazine,
Page 69 and 70: Guinea Pig 12 44 mg/kg IM with acet
Page 71 and 72: Rabbit 14 Diazepam 0.2-0.5 mg/kg IV
Page 73 and 74: Sheep 12Sheep 131.5 mg/ml ketamine,
Page 75 and 76: Swine 1 30 minutes 221Swine 2 20 mi
Page 77 and 78: Dog 2142, 277Once a day for 5 daysF
Page 79 and 80: All species Topical on skin 15 minu
Page 81 and 82: Sheep 3 0.005 mg/kg IV 221Sheep 3 0
Page 83 and 84: Goat 1 Up to 200 mg/kg IM total dos
Page 85 and 86: Dog 2 0.7-1.0 mg/kg epidural 277Dog
Page 87 and 88: DogOften use flow rate of 15 ml/min
Page 89 and 90: MIVACURIUM (Mivacrom)Class Nondepol
Page 91 and 92: Guinea Pig 1 2-3 hours 5, 10 , 4 ho
Page 93 and 94: Primate 2 6 hours 76Rabbit 1 4-5 ho
Page 95 and 96: Dosage frequencyDog Every 24 hours
Page 97 and 98: Primate 1, 21, 2193-6 hoursRabbit 3
Page 99 and 100: Cat 3 6 hours 121Dog 1 4 hours 12 ,
Page 101 and 102: Cat 115-30 minutesCat 3 6 hours 72D
Page 103 and 104: Dog 1 8 hours 20Dog 1 up to 7 days
Page 105 and 106: Dog 1 0.11 mg/kg IV 178Dog 2See Met
Page 107 and 108: Dosage frequencyDog 15 minutes 50Co
Page 109: Cat 1, 2 Subsequent doses are ½ or
Page 113 and 114: Swine 22.2 mg/kg IM with xylazine,
Page 115 and 116: ClassSourceAnestheticAldrich, Pfalt
Page 117 and 118: Swine 1 10 minutes 216 4 minutes 21
Page 119 and 120: CommentsCalf Will cause hyperglycem
Page 121 and 122: References1. Bacher, J. Primate Ane
Page 123 and 124: 29. Product insert for Ketaset (For
Page 125 and 126: 65. Silverman, J., Huhndorf, M., Ba
Page 127 and 128: 98. Malm, T., Bowald, S., Bylock, A
Page 129 and 130: 129. Vainio, O. and Ofala, M. Medet
Page 131 and 132: 172. Whelan, G. CompMed e-mail disc
Page 133 and 134: 211. J. Silverman, Clinical experie
Page 135 and 136: 250. Cooper, D. CompMed e-mail disc
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A COMPENDIUM OF DRUGS USED FOR LABORATORY ANIMAL ...

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