A COMPENDIUM OF DRUGS USED FOR LABORATORY ANIMAL ...

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Rat 2 0.5 ml/kg IM with midazolam (5 mg/ml) IM. 1:1 ratio. 37Anesthesia.Sheep 0.5 ml/4 kg for under 30 kg 37Swine 24.5 mg/kg with diprenorphine (Revivon) 0.3 mg/kg 3AntagonistDog Diprenorphine (q.v.) 62CommentsCat Adequate for immobilization and minor surgery 37DogAdequate analgesia for minor to moderate surgery.Bradycardia (use atropine). 37Rabbit Adequate for immobilization and minor surgery. 37 Notrecommended due to respiratory depression. 111EUGENOL (Clove Oil)Class Fish anestheticSource Health food storesFish 40-100 mg/liter 279CommentsFishUse 95% ethanol to create a stock solution of 100 mg/ml.Add to induction chamber water. 279FENOPR<strong>OF</strong>EN (Nalfon)Class Nonsteroidal anti-inflammatory analgesicSource Dista, Lederle Standard, MylanDog 0.5-1.0 mg/kg 148Dosage frequencyDog Every 24 hours 148FENTANYL (Sublimaze) Often combined with Droperidol as INNOVAR-VET. DoNot Use Human Formulation of Innovar. Innovar-vet is no longeravailable.Class Opioid containing neuroleptanalgesic, tranquilizer, mild anesthetic (αadrenergicblocker). Controlled substance.Source AstraZeneca, Elkins-Sinn, Abbott, Baxter, Janssen (transdermal patch)Amphibian (And see Frog). 1.0-2.0 mg/kg SC in dorsal lymph sac. 278Cat 1 0.1 mg/kg IM. 20 See comments.Cat 220 mg/kg IV (without droperidol) with diazepam 0.5 mg/kgIV. Anesthesia induction.Cat 3 25 µg/hour transdermal patch. 246
Cat 4 5.0-10.0 µg/kg epidural 277Dog 1 0.02-0.04 mg/kg IM (without droperidol) 4 SC, IV 220Dog 2 1 ml/10-20 kg IV as drip or given slowly, preanesthesia 4Dog 31 ml/7-10 kg IM 6 with droperidol. Analgesia andtranquilization 72Dog 4 1 ml/15-30 kg with droperidol, slowly, IV 6 Anesthesia 72Dog 5 1 ml/18 kg IM with droperidol. Anesthesia 72Dog 620 mg/kg IV (without droperidol) with diazepam 0.5 mg/kgDog 7IV. Anesthesia induction.Without droperidol. Oxymorphone 0.05 mg/kg,glycopyrrolate 0.02 mg/kg (premedication). Induce at 10-20 µg/kg IV with 0.1 mg/kg midazolam IV. Maintain withfentanyl 0.7-1.0 µg/kg/min IV and midazolam 0.35 µg/kg.Can use with isoflurane (0.5%) and atacurium (q.v.). 151Dog 8 50 µg/hr transdermal patch for 1-3 days. 220Dog 9 5.0-10.0 µg/kg epidural 277Dog 10 0.001-0.005 mg/kg IV 277 or drip at 0.003-0.010mg/kg/hour 277Ferret 1 0.5 mg/kg IM 148Ferret 2 Not Recommended 175Frog(Rana pipiens) 1.4 nmol/gram, dorsal lymph sac (withoutdroperidol) 148Gerbil 0.3-0.5 ml/kg IM, SC 175Goat 2.0 ml/kg IM 147Guinea Pig 1 0.66-0.88 ml/kg IP 2 , IM. 132 See comments.Guinea Pig 2 1 ml/kg IP with diazepam 2.5 mg/kg IP 2Guinea Pig 3 0.16 ml/kg IM. 20 See comments.Guinea Pig 40.32 mg/kg IM with diazepam 5.0 mg/kg IP given prior toInnovar-vet 217Hamster 1 Not satisfactory 28Hamster 2 1 ml/kg IP with diazepam 5 mg/kg IP 2Hamster 30.9 ml/kg IM. Analgesia with unpredictable degree ofsedation 177Hamster 40.9 ml/kg IM. Analgesia with unpredictable degree ofsedationMouse 1 0.01-5.0 ml/kg IM. 20 See comments. Immobilization andanalgesia 177Mouse 2 2.0-5.0 ml/kg of 1:10 dilution, IM, SC 175Primate 1 0.002 mg/kg IM, IV (analgesia, without droperidol) 1Primate 2 (Ape) 0.02 mg/kg IM (without droperidol) 147Primate 3 (Ape) 0.00008 IV (without droperidol) 147Primate 4 0.05-0.1 mg/g IV, IM 20Primate 5 0.1-0.2 mg/kg IM. 20 See comments.Primate 6 Baboon, mangabey, pigtail macaque 0.3-2.2 mg/kg IM 20Primate 7Macaque. Transdermal patch. 25 µg/kg/hr continuous IVinfusion 269
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A COMPENDIUM OF DRUGS USED FOR LABO
Page 3 and 4: SIGNS OF PAIN IN ANIMALSThe pain th
Page 5 and 6: Proposed Method to Quantify Pain, D
Page 7 and 8: needle is often used. To help preve
Page 9 and 10: GENERAL REQUIREMENTS FOR SURVIVAL S
Page 11 and 12: DETAILED CONSIDERATIONS FOR ANIMAL,
Page 13 and 14: SURGICAL SCRUB FOR THE SURGEONA. An
Page 15 and 16: RULES OF THUMB FOR ASSESSING THE NE
Page 17 and 18: Reptile:Sheep/Goat:Swine:meperidine
Page 19 and 20: ANALGESIA (8 OR MORE HOURS DURATION
Page 21 and 22: Reptiles:Sheep/Goat:Swine:ketaminea
Page 23 and 24: NEUROMUSCULAR BLOCKING/IMMOBILIZING
Page 25 and 26: fentanyl/droperidol, fentanyl/fluan
Page 27 and 28: A COMPENDIUM OF DRUGS USED FOR LABO
Page 29 and 30: Rabbit 3 0.1-0.2 mg/kg IV 21Rat 1 1
Page 31 and 32: ClassSourceNondepolarizing neuromus
Page 33 and 34: Rabbit 1 5-10 minutes 177Rabbit 2 8
Page 35 and 36: ClassSourceButyrophenone tranquiliz
Page 37 and 38: See commentsRabbit 50.5 mg/kg per r
Page 39 and 40: Rabbit 31.0 mg/kg SC, IM with acepr
Page 41 and 42: Bird 1-4 mg/kg IM 277Cat 1 2-4 mg/k
Page 43 and 44: Rat 12 hours 21 , 65 minutes (300 g
Page 45 and 46: Frog 30 mg/kg in dorsal lymph sac 2
Page 47 and 48: As long as gas is providedAntagonis
Page 49 and 50: Rabbit 11.0 mg/kg IM, IP 28 See com
Page 51 and 52: Cat 10.1-0.2 mg/kg IVCat 2 0.25-0.5
Page 53: Dosage frequencyDog 1, 25-10 minute
Page 57 and 58: Dog 1 30 minutes 220Dog 3 2 hours 6
Page 59 and 60: Gerbil 1 20-30 minutes 177Gerbil 2
Page 61 and 62: Guinea Pig76, 17512-24 hoursHamster
Page 63 and 64: Dosage frequencyAs long as gas is s
Page 65 and 66: Rabbit 2 6-8 hours 269Rat 1 4 hours
Page 67 and 68: Bird 110-30 mg/kg IM with xylazine,
Page 69 and 70: Guinea Pig 12 44 mg/kg IM with acet
Page 71 and 72: Rabbit 14 Diazepam 0.2-0.5 mg/kg IV
Page 73 and 74: Sheep 12Sheep 131.5 mg/ml ketamine,
Page 75 and 76: Swine 1 30 minutes 221Swine 2 20 mi
Page 77 and 78: Dog 2142, 277Once a day for 5 daysF
Page 79 and 80: All species Topical on skin 15 minu
Page 81 and 82: Sheep 3 0.005 mg/kg IV 221Sheep 3 0
Page 83 and 84: Goat 1 Up to 200 mg/kg IM total dos
Page 85 and 86: Dog 2 0.7-1.0 mg/kg epidural 277Dog
Page 87 and 88: DogOften use flow rate of 15 ml/min
Page 89 and 90: MIVACURIUM (Mivacrom)Class Nondepol
Page 91 and 92: Guinea Pig 1 2-3 hours 5, 10 , 4 ho
Page 93 and 94: Primate 2 6 hours 76Rabbit 1 4-5 ho
Page 95 and 96: Dosage frequencyDog Every 24 hours
Page 97 and 98: Primate 1, 21, 2193-6 hoursRabbit 3
Page 99 and 100: Cat 3 6 hours 121Dog 1 4 hours 12 ,
Page 101 and 102: Cat 115-30 minutesCat 3 6 hours 72D
Page 103 and 104: Dog 1 8 hours 20Dog 1 up to 7 days
Page 105 and 106:
Dog 1 0.11 mg/kg IV 178Dog 2See Met
Page 107 and 108:
Dosage frequencyDog 15 minutes 50Co
Page 109 and 110:
Cat 1, 2 Subsequent doses are ½ or
Page 111 and 112:
Rat 1 30 mg/kg IV of 1.25% solution
Page 113 and 114:
Swine 22.2 mg/kg IM with xylazine,
Page 115 and 116:
ClassSourceAnestheticAldrich, Pfalt
Page 117 and 118:
Swine 1 10 minutes 216 4 minutes 21
Page 119 and 120:
CommentsCalf Will cause hyperglycem
Page 121 and 122:
References1. Bacher, J. Primate Ane
Page 123 and 124:
29. Product insert for Ketaset (For
Page 125 and 126:
65. Silverman, J., Huhndorf, M., Ba
Page 127 and 128:
98. Malm, T., Bowald, S., Bylock, A
Page 129 and 130:
129. Vainio, O. and Ofala, M. Medet
Page 131 and 132:
172. Whelan, G. CompMed e-mail disc
Page 133 and 134:
211. J. Silverman, Clinical experie
Page 135 and 136:
250. Cooper, D. CompMed e-mail disc
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