SUNDAY, APRIL 22 Across Societies – Experimental Biology

PATHOLOGY/PHARMACOLOGYB220 658.4 Action of hypertonic saline solution (NaCl7,5%) in pulmonary fi brosis in a rodent model of endotoxemia.R.C. Petroni, P. Biselli, M. Martins, S. Csaba and F. Soriano.Med. Sch. of Univ. of São Paulo and Univ. of Texas Med. Branch.B221 658.5 Expression of receptor activator of nuclearfactor-κB (RANK), RANK ligand, and osteoprotegerin in thenormal and E. coli lipopolysaccharide-treated horse lungs. S.Channabasappa, S. Singh and B. Singh. Western Col. of Vet.Med., Univ. of Saskatchewan and Col. of Vet. Sci., Ludhiana,India.B222 658.6 Safety evaluation of MJ33 as a potential invivo inhibitor of NADPH oxidase (NOX2) activation. I. Lee, J.Zagorski, C. Dodia, S.I. Feinstein and A.B. Fisher. Univ. ofPennsylvania.SUNDAYB223 658.7 Effect of postural change on the prevalenceof ventilator-associated pneumonia. R. Sato, T. Miyagawa, T.Aruga and R. Maruyama. Tohoku Univ. Grad. Sch. of Med.,Showa Univ. Grad. Sch. of Nursing and Rehabil. Sci. andShowa Univ. Sch. of Med., Japan.B224 143.3 Transgenic mice overexpressing anendothelial-targeted Fas-inducing apoptosis construct exhibitpulmonary hypertension associated with marked lung arterialremodeling. H. Goldthorpe, S.A. Parsons, J-Y. Jiang, Y. Dengand D.J. Stewart. Ottawa Hosp. Res. Inst. and Univ. of Ottawa.Pharmacology and Experimental Therapeutics659. DRUGS OF ABUSE—COCAINEPosterSUN. 7:30 AM—SAN DIEGO CONVENTION CENTER, EXHIBITHALLS A-DPresentation time: 12:30 PM-2:45 PMB1 659.1 The effect of PKMζ inhibition on cocaineinducedplace preference and locomotor sensitization. K.Howell, S.A. Carmack and S.G. Anagnostaras. UCSD.B2 659.2 Effects of 5-HT2A receptor antagonism oncocaine self-administration, cocaine-induced reinstatement,and cocaine-induced dopamine overfl ow in rhesus monkeys.J.E. Winschel, K.S. Murnane, S. Stewart and L.L. Howell.Emory Univ.B3 659.3 Effects of subtype selective dopamine receptoragonists on progressive ratio responding for cocaine- andremifentanil-paired stimuli. J.W. Bertz and J.H. Woods. Univ.of Michigan.B4 659.4 Rimcazole attenuates the cocaine-inducedstimulation of mesolimbic dopamine related to its abuse anddependence. M. Mereu, L.E. Chun, T. Hiranita, J.J. Cao, A.H.Newman, J.L. Katz and G. Tanda. NIDA/NIH, Baltimore andUniv. of Colorado Boulder.B5 659.5 Effects of chronic methylphenidate treatmenton the reinforcing strength of cocaine in rhesus monkeys. P.W.Czoty, S.E. Martelle, R.W. Gould and M.A. Nader. WakeForest Univ. Sch. of Med.B6 659.6 Cognitive-disrupting effects of cocaine as aneffect of menstrual cycle phase. S.A. Kromrey, R.W. Gouldand P.W. Czoty. Wake Forest.B7 659.7 Can the stereotypy-inducing effects of atypicaldopamine uptake inhibitors account for their blockade ofcocaine self-administration? T. Hiranita, L. Li, S. Hayashi, J.J.Cao, A.H. Newman and J.L. Katz. NIDA/NIH, Baltimore.B8 659.8 In vivo study: developmental alterations inprimary rat neuronal and glial cell cultures following prenatalcocaine exposure. M.L. Johnson, T. Womble, T. Jackson andC.B. Goodman. Florida A&M Univ.B9 659.9 Effects of dopamine beta-hydroxylase inhibitionon cocaine-induced reinstatement in squirrel monkeys. D.A.Cooper, H. Kimmel and L. Howell. Emory Univ.B10 659.10 Humanizing the lambda light chain of thehuman/murine mixed-chain anti-cocaine monoclonal antibody2E2. W.J. Ball, M.R. Tabet, R. Wilton and A.B. Norman. Univ.of Cincinnati and Argonne Natl. Lab.B11 659.11 Assessment of dopaminergic involvement incocaine-induced conditioned taste aversions. K.M. Serafine,M.A. Briscione, K.C. Rice and A.L. Riley. American Univ. andNIDA and NIAAA/NIH.B12 659.12 Effects of cocaine self-administration oncognition in monkeys and evaluation of cognitive enhancementas a therapeutic strategy. R.W. Gould and M.A. Nader. WakeForest Univ. Sch. of Med.B13 659.13 Cocaine dose and self-administration history,but not initial cocaine-induced locomotor responsiveness,affect sensitization to the motivational effects of cocaine in rats.B.H. Mandt, E. Gomez, N.L. Johnston, N.R. Zahniser andR.M. Allen. Univ. of Colorado Denver and Univ. of ColoradoSch. of Med., Aurora.660. DRUGS OF ABUSE—DEPRESSANTS/CANNABINOIDSPosterSUN. 7:30 AM—SAN DIEGO CONVENTION CENTER, EXHIBITHALLS A-DPresentation time: 12:30 PM-2:45 PMB14 660.1 Dry ethanol gas testing of personal usebreathalyzers. M. Blackburn and J.R. Lee. West Texas A&MUniv.B15 660.2 Varenicline attenuates relapse-like ethanoldrinking behavior in mice. R.K. Sajja and S. Rahman. SouthDakota State Univ.B16 660.3 Age difference in behavior induced from coadministrationof nicotine and alcohol. A. Larraga, C.N. Chew,C. Gadalla, J.D. Belluzzi and F.M. Leslie. Univ. of California,Irvine.B17 660.4 Conditioned taste aversion elicited by syntheticcannabinoid JWH-018 in mice is attenuated by pretreatmentwith phytocannabinoid δ 9 -THC. W.S. Hyatt, S.M. Zimmermanand W.E. Fantegrossi. Hendrix Col., AR and Univ. of Arkansasfor Med. Sci.184