SUNDAY, APRIL 22 Across Societies – Experimental Biology

PHARMACOLOGYB137 673.4 Selective activation of human pregnane Xreceptor, glucocorticoid receptor, and constitutive androstanereceptor by individual ginkgolides. A.J. Lau, G. Yang andT.K.H. Chang. Univ. of British Columbia.B138 673.5 The orphan receptor/corepressor DAX-1 modulates human CAR transcriptional activity. E.M.Laurenzana, T. Chen, B. Sell, M. Kannuswamy, Y. Li and C.J.Omiecinski. Penn State and Univ. of Pittsburgh.B139 673.6 Silencing the estrogen receptor promoterusing DIF-1, a naturally occurring differentiation molecule ofthe cellular slime mold Dictyostelium discoideum. M. Bratton,W. Stutts, A. Pandey, M. Burow and J. McLachlan. TulaneUniv. Sch. of Med. and Univ. of Florida.B140 673.7 Selective estrogen-receptor modulatorsgenistein, resveratrol, and catechin fail to stimulate the hepaticexpression of estrogen-responsive genes encoding the avianapolipoprotein II and vitellogenin. V.D. Bhatt, K. Chaudhary,A. Bin Ariff, R. Boggeti and W.N. Ratna. Arnold & MarieSchwartz Col. of Pharm., Long Island Univ.B141 673.8 An active extract of Ulmus pumila inhibitsadipogenesis by inducing cell cycle arrest in 3T3L1 cells. C.Ghosh, H-Y. Chung, R.M. Nandre, I-S. Kim, S.H. Yang andS-G. Hwang. Hankyong Natl. Univ., Chonbuk Natl. Univ.,Konkuk Univ. and Natl. Inst. of Animal Sci., South Korea.B142 673.9 Retinoic acid related orphan nuclear receptorα induces cholesterol 12α hydroxylase (CYP8B1) genetranscription. P.S. Pathak, T. Li and J.Y.L. Chiang. NortheastOhio Med. Univ.B143 673.10 Downregulation of 3-hydroxy-3-methyl glutarylcoenzyme-A reductase in HEPG2 cells using shRNA. K.J.Shah, K. Patel, V.D. Bhatt, R. Boggeti and W.N. Ratna. Arnold& Marie Schwartz Col. of Pharm., Long Island Univ.B144 673.11 Regulation of SULT1C2 expression byendogenous isoprenoids in primary cultured rat hepatocytes. Z.Duniec-Dmuchowski, A.A. Dombkowski, T.A. Kocarek andM. Runge-Morris. Wayne State Univ.B145 673.12 Effects of T- and B-cell defi ciency on regulationof hepatic P450 enzymes in mice infected with an intestinalpathogen. E.T. Morgan, W.J. Watkins, R.D. Kinloch and B.A.Nyagode. Emory Univ.B146 673.13 Changes in liver metabolic gene expressionafter radiation exposure. V.E. Wotring and C.P. Peters. NASAJohnson Space Ctr. and Bethel Univ., MN.B147 673.14 The role of p300-HAT in promoter-associatedhistone acetylation and regulation of FasL gene expressionin ethanol treated CD4 + T lymphocytes. S. Ghare, M. Patil, S.Joshi-Barve, C. McClain and S. Barve. Univ. of Louisville andLouisville VA Med. Ctr.B148 673.15 Histone deacetylation is the primary epigeneticmechanism for silencing of tumor suppressor gene-tissuefactor pathway inhibitor-2 in hepatocellular carcinoma cells. A.Moghe, D. Barker, S. Ghare, L. Gobejishvili, S. Joshi-Barve,A. Barve, C. McClain and S. Barve. Univ. of Louisville.B149 673.16 The role of alternative polyadenylation inmediating stress-induced protein expression of Hsp70.3. M.Tranter, M. McGuinness, R.N. Helsley, W.R. Paulding, C.Brokamp, L. Haar, X. Ren and W.K. Jones. Univ. of Cincinnatiand Xavier Univ., OH.B150 673.17 Lactobacillus rhamnosus GG treatmentpotentiates intestinal hypoxia-inducible factor, promotesintestinal integrity, prevents infl ammation, and amelioratesalcohol-induced liver injury. Y. Wang, Y. Liu, I. Kirpich, C.McClain and W. Feng. Univ. of Louisville.B151 673.18 Hypoxia-induced lipid accumulation involvesa HIF-α independent, oxidative stress-mediated regulation ofFGF-21 in HepG2 cells. Y. Liu, Y. Wang, C.J. McClain and W.Feng. Univ. of Louisville.674. DEVELOPMENTAL PHARMACOLOGY/TOXICOLOGYPosterSUN. 7:30 AM—SAN DIEGO CONVENTION CENTER, EXHIBITHALLS A-DPresentation time: 12:30 PM-2:45 PMSUNDAYB152 674.1 The African clawed frog (Xenopus laevis) issensitive to pyrene exposure during early development. D.B.Snoke, K.E. Rosato, E.M. Richardson and S.L. Whittemore.Keene State Col., NH.B153 674.2 Dichloroacetonitrile induces proteinmodifi cations in cortical astrocyte cell line CTX-TNA2 andalterations in fetal mouse brain. A. Esmat, A.E. Khalifa, E.El-Demerdash, A.B. Abdel-naim, M.A. El-Mahdy and J.L.Zweier. The Ohio State Univ., Fac. of Pharm., Ain Shams Univ.,Egypt.B154 674.3 Distinct generation, pharmacology, anddistribution of sphingosine 1-phosphate and dihydrosphingosine1-phosphate in human neural progenitor cells. P.Callihan, N.C. Zitomer, M.V. Stoeling, P.C. Kennedy, K.R.Lynch, R.T. Riley and S.B. Hooks. Univ. of Georgia, USDA,Athens and Univ. of Virginia.B155 674.4 Organophosphate pesticide exposure affectszebrafi sh developmental physiology. H. Garcia, N. Hole, F.Radoniqi, H. Schmidt, G. Orona and E.A. Fradinger. WhittierCol., CA.B156 674.5 Synergistic effect of cysteinyl leukotrienereceptor antagonist and H-1 receptor antagonist in acute andchronic guinea pig asthma models. R. Alluri, K.V. Routhu, M.Nadendla and H. Emandi. Vishnu Inst. of Pharmaceut. Educ.and Res., Incozen Therapeut. pvt Ltd., Hyderabad, Shri VishnuCol. of Pharm. and Shadan Women’s Col. of Pharm., India.B157 674.6 Changes in the expression and function ofbeta-adrenergic receptors subtypes in the rat aorta duringdevelopment. O.A. Lopez-Canales, H. Vargas-Robles,M. Arellano-Mendoza, J. Lopez-Canales, M.C. Castillo-Hernandez, G. Guevara-Balcazar and B. Escalante-Acosta.Sch. of Med. and Cinvestav, IPN and Natl. Inst. of Perinatol.,Mexico City.190