Gamma-hydroxybutyric acid – GHB Gamma-butyrolactone - GBL 1,4 ...

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GHB blood levels in anesthesia• 16 adults - correlation of state of consciousness with GHBlevel• Doses: 50, 75, 100 and 165 mg/kg• Range of 100 mg/kg dose = 234 to 520 mcg/ml• 12 of the 16 patients required intubation• Not necessarily those who received the highest GHBdoses (Helrich et al.1964)
GHB levels vs arousal states inhumans in mcg/mLSleep State = Awake Light Sleep Medium Sleep Deep SleepGHB µg/mL* 0 - 99 63 - 265 151 - 293 244 - 395Table 1 * values converted from micromoles/L
Page 1 and 2: Pharmacology, Toxicology and Analys
Page 3 and 4: Formation of GHB from GABAOH 2 NOHG
Page 5 and 6: • Synthesized in 1960 by Laborit
Page 7 and 8: Some Clinical Uses of GHB• Anaese
Page 9 and 10: HOOHH 2 NOHGHBOGABAOOOHO1,4 BDOHGBL
Page 11 and 12: GHB - names• Gamma OH• Sodium o
Page 13 and 14: Growth Hormone Release• Does incr
Page 15 and 16: Amnesia ??• Anecdotal reports of
Page 17 and 18: NADP+NADPHOHOOHGHB dehydrogenaseHOH
Page 19 and 20: GHB dehydrogenase inhibitors• Nat
Page 21 and 22: Chemical Synonyms for GBLdihydro-2(
Page 23 and 24: Metabolism of GBLIn vivo: blood and
Page 25 and 26: What is 1,4 Butanediol (1,4BD)?•
Page 27 and 28: Chemical Synonyms for 1,4BDCHEMICAL
Page 29 and 30: 1,4 BD metabolism• The activity o
Page 31 and 32: High Times Mag. 1998• Hey, Lisa I
Page 33 and 34: Where can you get GHB, GBL or 1,4BD
Page 36: •GBLProduct
Page 39: Dose Response of GHB• < 1 gram -
Page 44 and 45: Contrast blood levels seen in Alcoh
Page 46 and 47: Outcome of toxic dose• Respirator
Page 48 and 49: GHB is addictive• Chronic use of
Page 50: Interactions• GHB potentiates CNS
Page 53 and 54: Methodologies for GHB AnalysesDetec
Page 55 and 56: Analytical Concerns - I• GHB is r
Page 57 and 58: Formation of GHB from GABAOH 2 NOHG
Page 59 and 60: Does more advanced decompositionmea
Page 61 and 62: GHB and GBL EquilibriumOGBLObasic p
Page 63 and 64: GHB scheduling has curbedillicit GH
Page 65 and 66: Case Studies (DUI)• 12/98 JR “R
Page 67: Case Studies Cont (DUI)• 8/99 AB-
Page 73 and 74: Case Studies• Non fatal GHB - WCM
Page 75 and 76: Case Studies Cont(Overdoses)• Fat
Page 77 and 78: Case Studies Cont - Overdoses• Fa
Page 81 and 82: Case Studies• Fatal overdose - WC
Page 85 and 86: GBL and 1,4BD are the onlyGHB-like
Page 87 and 88: “The Science:Tranquil-G is the tr
Page 89 and 90: What is Gamma-valerolactone??• FD
Page 91 and 92: Startle Amplitude (% Control)120100
Page 93 and 94:
In vivo: blood and liver(Fishbein a
Page 95 and 96:
Conclusions I• Interpretation of
Page 98:
• Gamma-hydroxybutyrate; Molecula
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Gamma-hydroxybutyric acid – GHB Gamma-butyrolactone - GBL 1,4 ...

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