Ch18 Amines(pdf) - KFUPM Open Courseware
Ch18 Amines(pdf) - KFUPM Open Courseware
Ch18 Amines(pdf) - KFUPM Open Courseware
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Preparation of <strong>Amines</strong>Techniques fall into three major categories:1) Nucleophilic Substitution2) Reduction3) Amide rearrangement18.4 APreparation of <strong>Amines</strong>by Alkylation of AmmoniaDesired reaction is:Alkylation of Ammonia2 NH 3 + R—X R—NH2+ NH 4 XDesired reaction is:Alkylation of Ammonia2 NH 3 + R—X R—NH2+ NH 4 Xvia:H 3 N • + R•• + •• X •• H 3 N R ••–+ •• X •• ••then:H 3 N • + HH++N R H 3 N H +H•• NRHH