The Genetic Basis of White Tigers - abc

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SLC45A2 structure predictionPeriplasmTM1TM8TM6TM5TM3TM4TM10TM9NA477CTM2A477VTM11TM7TM12Cytoplasm
How does SLC45A2 determinepigmentation ?• SLC45A2 locates on the membrane of melanosome inmelanocyte.• SLC45A2 shares similar structure and the signaturedomain of sucrose/proton co-transporter in plants.• SCRT, the Drosophila melanogaster homology ofSLC45A2, is proved to be a sucrose/proton co-transporter.• The activity of tyrosinase (TYR) is regulated by themelanosomal pH.
Page 1 and 2: The Genetic Basis of White TigersXi
Page 5 and 6: Objective of this study
Page 7 and 8: Candidate sequencingapproachCystein
Page 9: Alternative Strategy13 offspring ti
Page 13 and 14: Causal mutation screeningGeneCDS SN
Page 15: Prediction of A477V impactNewton et
Page 19 and 20: How does SLC45A2 determinepigmentat
Page 21: Acknowledgements• Dr. Shu-Jin Luo

The Genetic Basis of White Tigers - abc

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