The Genetic Basis of White Tigers - abc

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How does SLC45A2 determinepigmentation ?• The activity of SLC45A2 in underwhite mouse was onlyabout 20% of that found in wild type mouse.• Premature melanosome was secreted in underwhitemouse.• Crenated melanosome was found in the melanocyte ofunderwhite mouse.
How does SLC45A2 determinepigmentation ?We proposed: SLC45A2 is a sucrose/proton cotransporterand mediate melanin synthesis byregulating melanosomal pH and/or osmoticbalancing.
Page 1 and 2: The Genetic Basis of White TigersXi
Page 5 and 6: Objective of this study
Page 7 and 8: Candidate sequencingapproachCystein
Page 9: Alternative Strategy13 offspring ti
Page 13 and 14: Causal mutation screeningGeneCDS SN
Page 15 and 16: Prediction of A477V impactNewton et
Page 17: How does SLC45A2 determinepigmentat
Page 21: Acknowledgements• Dr. Shu-Jin Luo

The Genetic Basis of White Tigers - abc

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