The Genetic Basis of White Tigers - abc

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Candidate sequencing resultsCandidate geneSequencingregionNO of SNPsidentifiedPhenotypeassociated SNPsMC1R CDS 1 noneASIP CDS 1 noneTYR CDS, UTRs 2 noneTYRP1 CDS 1 noneSLC7A11 CDS 2 noneSLC18A2 CDS 0 none• 5 white tigers and 5 orange tigers
Alternative Strategy13 offspring tigers (F 1 )RAD sequencing and SNP detectionSNP markers3 parental tigers (F 0 )Genome-wide linkage mappingTrait-associated chromosome regionsWhole-genome sequencingGWASLD and haplotype analysisBoundary of candidate genome regionGenome sequence andpolymorphisms between genomesMutationscreeningSearching for candidate mutationsin the candidate regionCandidate genes with non-sysnonymous mutationsCausative gene and mutation siteValidation and extended study in 130unrelated tigers (20 white and 110 wild-type)Functional characterization
Page 1 and 2: The Genetic Basis of White TigersXi
Page 5 and 6: Objective of this study
Page 7: Candidate sequencingapproachCystein
Page 13 and 14: Causal mutation screeningGeneCDS SN
Page 15 and 16: Prediction of A477V impactNewton et
Page 17 and 18: How does SLC45A2 determinepigmentat
Page 19 and 20: How does SLC45A2 determinepigmentat
Page 21: Acknowledgements• Dr. Shu-Jin Luo

The Genetic Basis of White Tigers - abc

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