Argonaut Quest Training Workshop 2 (pdf) - Artisan Scientific

High YieldLow levels ofimpuritiesEnhanced ResinPropertiesArgonaut Technologies has developed ~ r~o~el@ resin -- a family of productsbased on a new polyethylene glycol-polystyrene graft (PEG/PS) co-polymer.These support materials are exceptionally stable under the rigors of solidphase organic synthesis. ArgoGel resins provide a high loading capacity, lowlevels of impurities and exhibit compatibility with a broad range of organicreagents and solvents due to their unique structure and improved purificationprocess.9 High Loading Capacity for High YieldsArgoGel resins provide yields approximately two-fold higher than comparableresins. The copolymer is built on a novel framework consisting of twice thenumber of groups per backbone attachment site. This results in higher loadingcapacity per unit weight without sacrificing the benefits conferred by thepolyethylene glycol graft. ArgoGel-OH and -NH2 have loading values in therange of 0.4-0.5 mmole per gram based on standard analytical techniques.Solvent-swollen ArgoGelbeads provide a solution-likeenvironment for solid-phasesynthesis.2 Low levels of impuritiesJChemical StabilityArgoGel supports enable production of higher purity products. ArgoGelemploys an inert 1,3 diol construct which is linked directly to thepoly(styrene/divinylbenzene) core matrix through a carbon-carbon bond.This chemical linkage minimizes degradation of the PEG chain and loss ofloading by aggressive reagents used during cleavage. The result is more pureproduct per gram of resin.Artisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com