Argonaut Quest Training Workshop 2 (pdf) - Artisan Scientific

Scientific Resources Page 7 of 10"Solid-Supported Synthesis of Imidazoles: A Strategy for DirectResin-Attachment to the lmidazole Core"Bilodeau, M.T.; Cunningham, A.M., J. Org. Chem., 63, 2800-2801,1998.Related Argonaut Product: ArgoGel-MB-CHO"Alcoholysis and Carbonyl Hydrosilylation Reactions using aPolymer-Supported Trialkylsilane"Hu, Y.; Porco, J.A., Jr., Tetrahedron Letters, 39, 271 1-2714, 1998Polystyrene-diethylsilane (PS-DES) resin may be reacted with alcohols (alcoholysis) andcarbonyl compounds (hydrosilylation) in I-methyl-2-pyrrolidinone (NMP) using Wilkinson'scatalyst (RhCI(PPh3)3) to afford the corresponding resin-bound silyl ethers. The silyl ethersformed were effectively cleaved using HFIpyridine solution in THF. Methoxytrimethylsilanewas employed to scavenge excess HF from product solutions.Related Argonaut Product: PS-DESComplimentary reprints avadable by contacting ArgonautTechnolog~es."Analysis of 9-Fluorenylmethoxycarbonyl (FMOC) Loading ofSolid-Phase Synthesis Resins by Gas Chromatography"Newcomb, W.S., Deegan T.L , Miller, W. and Porco, J.A. ,Biotechnology and Bioengineering (Combmatorial Chemistry), vol. 61,No. 1, Winter, 1998.This technical article compares several sample manual and automated preparation methodsusing the Nautilus 2400 and finds that the Nautilus can be used to reduce operation time andincrease throughput of sample analysis."Automated Chemical Synthesis: Chemistry Development on theNautilusTM 2400"Porco, J.A. Jr.; Deegan, T.L.; Devonport, W.; Gooding, 0.; Labadie,J.W.; MacDonald, A.A.; Newcomb, W.S.; van Eikeren, P. Drugs of theFuture, 23 (I), pp. 71-78, 1998.The automation of the organic synthesis of small molecules is now a major focus in thepharmaceutical industry. Over the last few years, commercially available instrumentation forautomated organic synthesis has steadily increased, concomittant with the need forincreased throughput for chemistry development and library synthesis. However, it isapparent that further development of robust and inert instrumentation is required to facilitatethe automation of a broad range of synthetic organic chemistries, either on solid-support orusing conventional solution-phase methods. In this chapter, we will describe the Nautilus2400, a chemistry development workstation, and demonstrate examples of its ability 1) tohandle air- and moisture-sensitive reagents 2) to exhibit precise control over reaction time,and 3) to perform individual temperature control in segregated reaction vessels. The result isa useful tool for drug discovery which allows chemists to increase efficiency in chemistrydevelopment, lead optimization, and library synthesis.Related Argonaut Product: Nautilus 2400"Solid-Phase Synthesis of 2-Aminothiazoles"Kearney, P.C.; Fernandez, M.; Flygare, J.A., J. Org. Chem., 63, 196-200,1998.Related Argonaut Product: ArqoGel MB-CHOCombinatorial chemistry using polymer-supported reagentsArtisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com