<strong>Scientific</strong> Resources Page 5 of 10Copolymer Resin Supports for Solid-Phase Organic SynthesisGooding, O.W.; Baudart, S.; Deegan, T.L.; Heisler, K.; Labadie, J.W.;Newcomb, W.S.; Porco, J.A.,Jr; van Eikeren, P., Journal ofCombinatorial Chemistry 1999, 1,113.<strong>Argonaut</strong> Related Product: ArgoGel re-siParallel Synthesis of 1,2,3-Thiadiazoles Employing a "Catch andRelease" StrategyHu, Y.; Baudart, S.; Porco, J. A., Jr., J. Org. Chem., 1999, 64 (3),1049-1 0511,2,3-Thiadiazoles were synthesized in parallel on the <strong>Quest</strong> 210 using a polymersulfonylhydrazide resin (PS-TsNHNH*) employing a "catch and release" synthesis strategy"Resin capture" of ketones synthesized from Weinreb amides and Grignard reagents(quenched using MP-TsOH resin) afforded resin-bound sulfonylhydrazones. Cyclativecleavage of support-bound sulfonylhydrazones with thionyl chloride afforded 1,2.3-thiadiazoles. Excess thionyl chloride was neutralized using liquid-liquid extraction cartridges.Further functionalization reactions (Stille coupling) on resin-bound sulfonylhydrazones arealso described.Related <strong>Argonaut</strong> Products' <strong>Quest</strong> 210, PS-TsNHNH, MP-TsOHParallel Synthesis of 1,2,4-Oxadiazoles Using CDI ActivationDeegan, T. L.; Nitz, T. J.; Cebzanov, D.; Pufko, D. E.; Porco, J. A. ,Bioorganic and Medicinal Chemistry Letters,9 (2) 209-21 2 , 19991,2,4-Oxadiazoles were prepared in parallel on the <strong>Quest</strong> 210 using 1 ,I '-carbonyldiimidazole(CDI) as a reagent for both formation and cyclodehydration of 0-acyl benzamidoximes. Theuse of CDI facilitates parallel purification of the oxadiazole products by simple liquid-liquidextraction and filtration.Related <strong>Argonaut</strong> Product: <strong>Quest</strong> 210Polymer-assisted solution phase (PASP) chemical librarysynthesisFlynn et. al. Med. Chem. Res. 1998, 8:415 219-243.Solution-Phase Library Generation: Methods and Applications inDrug DiscoveryGayo, L.M. Biotechnology and Bioengineering (CombinatorialChemistry), 1998, 61, 2, p. 95.Gel phase MAS I-H NMR as a probe for suprarnolecularinteractions at the solid-liquid interfacede Miguel, R.Y.;Barnpos, N.; Nalin de Silva, K.M.; Richards, S.A.;Sanders, J.K.M., Chem. Commun., 1998,2267.<strong>Artisan</strong> Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com
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