Argonaut Quest Training Workshop 2 (pdf) - Artisan Scientific

-Product: PS-MB-CHOChemical Name: (4-Formyl-3-methoxyphenoxy)methylpolystyreneCapacity: 1.0 - 1.4 mmol/g (determined bynitrogen analysis of the 2,4-dinitrophenyl hydrazonederivative)Bead Size: 100 - 200 mesh (75 - 150 microns)Resin Swelling: CH,CI, (8.4 mL/g),THF (7.5mL/g), DMF (6.2 mL/g)Linker Functionality: AminesReaction Conditions Tolerated: Mildly acidic,basicTypical Cleavage Conditions: Activation withan isocyanate, sulfonyl chloride or acyl derivativefollowed by tratment with 95:5 trifluoroaceticacid:water or 95:5 trifluoroacetic acid:triethylsilane.Efficiences for cleavage depend on thenature of the amine and electrophile subsituent.Products: Amines, amides, sulfonamides, ureas,heterocyclesRecommended Agitation: Gentle magneticstirring, rocking, or overhead stirring for largeresin quantities (> 5g)This resin is useful for attachment of amines byreductive amination.' The conditions for reductiveamination are similar to those reported for ArgoGel-MB-CHO [A], with the exception that sodium borohydridein THF/ethanol (3: 1) is used as the reducingagent."") Activation with an isocyanate, sulfonylchloride or acyl derivative can be used as a diversitystep allowing the preparation of amides, sulfonamidesand ureas.References1. (a) Fivush, et al., Tetrahedron Lett., l997,38,7 15 1. (b) Sarantakis, D., Tetrahedron Lett., 1997,38,7325.[A] ArgoGel-MB-CHO Data Sheet,ArgonautTechnologies, DS-0 12.General References for MB-CHO LinkerBilodeau, M.T.; Cunningham, A.M., J. Org. Cbem.,1998,63,2800.Kearney, PC.; Fernandez, M.; Flygare, J.A., J. Org.Cbem., 1998,6.?, 196.Swayze, E., Tetrahedron Lett., 1997, 38,8465.-part #Qty800352 10 g800298 25 g800299 100 g800327 50 #3 ArgoCaps800328 100 #3 ArgoCaps800329 500 #3 ArgoCaps800330 1000 a3 ArgoCaps800343 50 #5 ArgoCaps800344 100 #5 ArgoCaps800345 500 #5 ArgoCaps800346 1000 a5 ArgoCapsArtisan Technology Group - Quality Instrumentation ... Guaranteed | (888) 88-SOURCE | www.artisantg.com