—772 Quinine Ether. [November)Two or three times subsequently, I covered the edges againwith the zinc paste; after which I left the wound to cicatrize,under the application of dry lint. I touched the conjunctiva<strong>and</strong> papillae lacry males occasionally with the four grains' solutionof nitrate of silver, under which application they speedilyfreed themselves of inflammation.On the 24th March, the patient called on me, with a firmcicatrice, of a healthy hue, in the site of his former disease.Ophthalmic Hospital Reports, <strong>and</strong> Ibid.Quinine Ether.M. ElSSEN" has recommended in the Gazette Medicate de Strasbourg,the use of quinine, introduced into the air-passages, forthe treatment of intermittent fevers. The process consists inthe inhalation of quinic ether, a combination made by M. Manette,<strong>and</strong> first used by M. Pignacci, of Milan.The substance, still incompletely defined, in a chemical pointof view, is obtained by means of the distillation of alcohol,treated by sulphuric acid, (theory of ethers,) in presence of thequinate of lime. The product of this distillation is a liquid perfectlylimpid, colorless, of an agreeable odor, less volatile thansulphuric ether, but still sufficiently volatile to evaporate at anordinary temperature without leaving -a deposit. It deserves,then, the name of ether ;<strong>and</strong> its therapeutical action, besides,seems to justify the qualification of quinic, which has been givento it.Quinic ether, says M. Eissen, fills all the necessary conditionsof a good therapeutical agent. It acts, at the same time, tuto,cito etjucunde. Inhaled in the dose of a few grammes, (2 to 3,)as chloroform is generally employed upon a compress, it checks& commencing access, <strong>and</strong> prevents a return of subsequent accesses.In all the cases in which it was tried, the access graduallyyielded, never to return, when the fever was simple, or undera very mild form in cases of decided cachexia.Since the first trial upon patients in Lombardy, who couldnot be suspected of being slightly affected, other trials have beenmade by Prof. Groh, at Olmutz, <strong>and</strong> with the same success.The results have been the same : whether the inhalation wasmade before or during the pyrexia, the access was lessened incharacter in a marked degree, <strong>and</strong> the next anticipated accessprevented, in the majority of cases; the tumefaction of thespleen disappearing at the same time. The inhalation, far frombeing disagreeable, was followed by good results, or of a sensationof decided amelioration. We may add that, in their experiments,our learned confreres, whpse names we have cited, were
—1859.] Vegetation of the Genital Organs. 773careful to establish negative proofs to confirm their judgment.They submitted a certain number of fever-patients to in halation aof pure sulphuric ether, or sulphuric ether holding sulphate ofquinine in solution. The inhalations of pure ether produced noother effect than that of increasing, in an insupportable manner,the hot stage; while in those taking the ether containing thequinine, some anti-periodic effects were observed, after largequantities of the remedy were absorbed; but in severe casesthese effects were so slight, after long trials, that the patientsthemselves solicited more energetic measures. \_Amer. Mtd. Mon.Vegetation of the Genital Organs— Chromic Acid. [Translatedfrom the Gazette Hebdomadaire for the Boston Med. <strong>and</strong> Surg.<strong>Journal</strong>] By 0. D. Palmer, M. 1)., Zelienople, Pa.Case.— 0., 23 years of age, of a good constitution, never havingbeen diseased, became pregnant ibr the first time toward the endof October, 1856. About the same time she was taken with anabundant blennorhagic discharge. Having arrived at the fourthmonth of gestation, she experienced a sense of heat <strong>and</strong> sufferingin the genital organs. This painful sensation was producedby the presence of numerous prominences in the vagina,which had replaced the very copious <strong>and</strong> extremely foetid purulentdischarge. Careful cleanliness, injections, <strong>and</strong> baths, procuredno ease. Two months passed, during which the diseasewas making rapid progress.C. presented herself at the hospital, where she was admittedon the 30th of April, in the sixth month of her pregnancy. Itwas ascertained that over the labia majora <strong>and</strong> minora the vaginalcanal, <strong>and</strong> even the cervix uteri, was a growth of excrescencesof considerable size, <strong>and</strong> in great number. The mostvoluminous, as large as the fist, projected outside of the vagina.Of these vegetations some were with pedicles, others were sessile;their tints were reddish, their appearance vascular. Theywere for the most part divided <strong>and</strong> subdivided, forming ramifications,which in their aspect offered some analogy to the corymbof the millifolium. In the vagina these excrescences hadacquired such dimensions, such a development, as to fill all thecavity, <strong>and</strong> not to permit, without the greatest difficulty, the introductionof the speculum.In searching for the cause of these vegetations, it was impos-The woman hadsible to recognize for them a syphilitic origin.never had chancres. An attentive examination of the genital partsdid not discover any ulceration. There existed no engorgementof the inguinal or sub-occipital gl<strong>and</strong>s, no squamous eruption.In such a state of things we could not but foresee great difficultyat the time of accouchement. It was, then, very important
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