PEPROTECH ®www.peprotech.comFGF FamilyFibroblast Growth Factor familyFibroblast Growth FactorsMW-Secretedform (murine)EstimatedpITarget Cells(Partial List)ReceptorsFunctions(Partial list)FGF1 (Acidic FGF) 15.8 7.99 mesenchymal, all FGF Angiogenic in vivo,Heparin-binding growth factor-1 (HBGF-1) (15.7kDa) (7.88) neuroectodermal receptors Mitogenic in vitro,Beta-endothelial cell growth factor endothelial cells wound healingECGF-beta (endothelial cell growth factor-beta)FGF2 (Basic FGF) 17.2 10.03 mesenchymal, 1b,1c, Vasculogenesis, woundHeparin-binding growth factor-2 (HBGF-2) (17.1kDa) (9.59) neuroectodermal 2c, 3c,4 healing, angiogensis,Prostatropin endothelial cells hematopoiesis,neuron survivalFGF3 24.9 10.98 epithelial cells 2b Mesoderm induction,int-2 (25.2kDa) (10.84) that express FGF angiogenesis, inner earreceptor 2bdevelopmentFGF4 19.7 10.22 cells that express 1c, Angiogenesis,Heparin secretory transforming protein (HST-1) (18.9kDa) (10.24) FGF receptors 2c, 3c,4 vertabrate limbTransforming protein KS3development andHeparin-binding growth factor-4 (HBGF-4)development ofstomach cancerFGF5 27.5 11.1 cells that express 1c,2c Hair growth andHeparin-binding growth factor-5 (HBGF-5) (27.1kDa) (10.50) FGF receptors developmentSmag-82FGF6 18.7 10.09 cells that express 1c,2c,4 Skeletal muscleHeparin-binding growth factor-6 (HBGF-6) (18.9kDa) (9.80) FGF receptors developmentHST-2FGF7/KGF (Kerotinocyte Growth Factor) 18.9 9.55 keratinocytes and 2b Keratinocyte growthHeparin-binding growth factor-7 (HBGF-7) (18.8kDa) (9.22) epithelial cells factor, kidney and lungthat express FGFdevelopment,receptor 2bangiogenesis andwound healingFGF8 22.4 10.95 mammary 2c,3c,4 Limb, centralAndrogen-induced growth factor (AIGF) (28.0kDa) (10.46) carcinoma cells (possibly 1c) nervous system,Heparin-binding growth factor-8 (HBGF-8) and other cells cardiac outflow tractthat expressdevelopmentFGF receptorsFGF9 23.4 7.44 glial cells, 1c,2c, Glia-activating factor,Glia activating factor (GAF) (23.3kDa) (7.44) astrocytes cells 3b,3c,4 motoneuron survival,Heparin-binding growth factor-9 (HBGF-9) and other cells lung and testesthat express FGFdevelopmentreceptorsINFORMATION & TECHNICAL SUPPORTFGF10 19.3 10.49 epithelial cells 2b Wound healing,FGFA (19.5kDa) (9.76) that express FGF multi-organKeratinocyte growth factor 2 receptor 2b development includinglimb and lungFGF11 25.0 9.92 none Appears to be involvedFGFB (25.1kDa) (10.06) in nervous systemFibroblast Growth factor homologousdevelopmentfactor-3 (FHF-3)and functionFGF12 27.4kDa 9.98 none Appears to be involvedFGFCin nervous systemFibroblast Growth factor homologousdevelopmentfactor-1 (FHF-1)and functionContinued…Bestellungen: Deutschland: Tel: 0800 436 99 10 • email: info@peprotech.dePour commander: France: Tel: +33 (0)1 46 24 58 20 • email: info@peprotechfr.comTo Order: NORDIC: Tel: +46 (0)8 640 41 07 • email: info@peprotech.se143
www.peprotech.com<strong>2011</strong>-<strong>2012</strong> <strong>Catalogue</strong>FGF Family ContinuedFibroblast Growth FactorsMW-Secretedform (murine)EstimatedpITarget Cells(Partial List)ReceptorsFunctions(Partial list)FGF13 27.5 9.92 none Appears to be involvedFGFD (27.6 kDa) (9.92) in nervous systemFibroblast Growth factor homologousdevelopmentfactor-2 (FHF-2)and functionINFORMATION & TECHNICAL SUPPORTFGF14 27.7 10.11 none Regulates centralFGFE (27.7 kDa) (10.11) nervous systemFibroblast Growth factor homologousdevelopmentfactor-4 (FHF-4)and functionFGF15 (22.5 kDa) (5.76) cells that express unknown at Regulator of cellFGFF, identified in mouse not human FGF Receptor 4 time of division and patterningprinting in specific regions ofembroyonic brain,spinal cord andsensory organsFGF16 23.7 kDa 9.52 cells that express 2c, 3c Central Nervous SystemFGFG FGF receptors developmentFGF17 22.7 11.22 cells that express 1c, 2c, Signals induction andFGFH (22.5kDa) (10.71) FGF receptors 3c, 4 patterning of embryonicbrainFGF18 21.2 10.67 cells that express 1c, 2c, An essential regulatorzFGF5 (20.9kDa) (10.09) FGF receptors 3c, 4 of long bone andFGFIcalvarial developmentFGF19 21.8 kDa 6.32 cells that express 4 Expressed during brainFGFJ, identified in human not mouse FGF Receptor 4 development andduring embryogenesisFGF20 23.2 kDa 9.22 epithelial and 1c, 2c, 3c Expressed during limbFGFK mesenchymal cells and brain developmentFGF21 19.4 5.29 unknown at unknown at Expressed in liverFGFL (19.9 kDa) (4.59) time of printing time of printingFGF22 17.1 11.71 hair follicle- unknown at May be involvedFGFM (16.5 kDa) (11.58) keratinocytes time of printing in cutaneousdevelopment & repair,and hair developmentFGF23 25.3 8.95 renal proximal 3c Expressed in brain andFGFN (25.3 kDa) (9.64) epithelial cells thymus, regulatesphosphate homeostasis,mutant in hypophosphatemicrickets.144To Order: EC: Tel: +44 (0)20 7610 3062 • email: info@peprotech.co.ukBestellungen: AUSTRIA: Tel: +43 (0)1 405 9696 • email: info@peprotech.atObjednávky: Česká Rep.: Tel: +420 225 992 284 • email: info@peprotech.cz