2011-2012 Catalogue - PeproTech, Inc.

PEPROTECH ®www.peprotech.comTGF-β Superfamily continuedNatural Antagonists/Name Synonyms Main Function Binding ProteinsBMP-3B GDF-10 Biological function unknown, but may play a rolein differentiation of osteoblasts, augmenting BMP-2activity.BMP-4 BMP2B (BMP2B1, Induces cartilage and bone formation, involved in Noggin, Chordin,BMP2B2, Bmp2-rs1) mesoderm induction, tooth development, limb Chordin-like/formation and fracture repair.Neuralin/DAN,Cerberus, GremlinBMP-5 None Induces cartilage and bone formation. Noggin, Chordinlike/Neuralin/Ventroptin,Sclerostin/SOSTBMP-6 Vgr-1, Induces cartilage and bone formation. Noggin, Chordin-Vg-1-related proteinlike/Neuralin/Ventroptin Follistatin,Follistatin-likerelated gene (FLRG),Sclerostin/SOSTBMP-7 OP-1 (Osteogenic protein-1) Induces cartilage and bone formation, involved in Noggin, Chordin,calcium regulation and bone homeostasis. May act Follistatin-relatedas an osteoinductive factor responsible for epithelial gene (FLRG),osteogenesis.DAN, Cerberus,Sclerostin/SOSTBMP-8 BMP-8a, Induces cartilage and bone formation, involved inOP-2 (Osteogenic protein-2) calcium regulation and bone homeostasis. May actas an osteoinductive factor responsible for epithelialosteogenesis.BMP-8b None Stimulates cartilage and bone formation, implicatedin calcium regulation and bone homeostasis.BMP-9 GDF-2 May be involved in bone formation, regulates bloodglucose homeostasis, potential autocrine/paracrinemediator in the hepatic reticuloendothelial system,involved in chondrogenesis.BMP-10 None Plays a crucial role in trabeculation of theembryonic heart.BMP-11 GDF-11 Involved in the patterning of both mesodermal Follistatin,and neural tissues and in establishing the skeletal Follistatin-likemuscle. Acts globally to specific positional identity related gene (FLRG),along the anterior/posterior axis.GASP-1BMP-12 GDF-7, CDMP-3 Induces the formation of tendon and ligamenttissues.BMP-13 GDF-6, CDMP-2 Plays a role in cartilage homeostasis, involved in the Nogginembroyonic skeletal development, and formation ofa tendon-like tissue.BMP-14 GDF-5, CDMP-1 Essential for limb cartilage and limb-joint formation Noggin, DANin developing mice. Involved in the embryonicskeletal development.BMP-15 GDF-9B An oocyte-specific factor that regulates granulosacell proliferation and differentiation, and is essentialfor normal follicular growth.GDF-1 Embryonic growth/ May be involved in mediating cell differentiationdifferentiation factor events during embryonic development.INFORMATION & TECHNICAL SUPPORTContinued…Bestellungen: Deutschland: Tel: 0800 436 99 10 • email: info@peprotech.dePour commander: France: Tel: +33 (0)1 46 24 58 20 • email: info@peprotechfr.comTo Order: NORDIC: Tel: +46 (0)8 640 41 07 • email: info@peprotech.se147