PEPROTECH ®www.peprotech.comTNF Superfamily NomenclatureTNF Superfamily – LigandsNomenclature NameTNFSF1ATNFSF1BTNFSF3TNFSF4TNFSF5TNFSF6TNFSF7TNFSF8TNFSF9TNFSF10TNFSF11TNFSF12TNFSF13TNFSF13BTNFSF14TNFSF15TNFSF18TNFSF20TNF Superfamily – ReceptorsNomenclature NameTNFRSF1ATNFRSF1BTNFRSF3/LTBR: (lymphotoxin beta receptor)TNFRSF4TNFRSF5TNFRSF6TNFRSF6BTNFRSF7TNFRSF8TNFRSF9TNFRSF10ATNFRSF10BTNFRSF10C: (decoy without an intracellular domain)TNFRSF10DTNFRSF11ATNFRSF11B(TNFRSF12)TNFRSF12ATNFRSF12LTNFRSF13BTNFRSF13CTNFRSF14TNFRSF16TNFRSF17TNFRSF18TNFRSF19TNFRSF19LTNFRSF21TNFRSF22TNFRSF23TNFRSF25TNFRSF26Note: This table is reflective of the current knowledge.Functional NamesTNF-alpha, Cachectin, DIF, TNFSF2TNF-beta, LT alpha, TNFSF1LT beta, TNFC, p33OX40 Ligand (OX40L), gp34, TXGP1CD40 Ligand (CD40L), IMD3, TRAP, gp39, CD154, HIGM1, hyper-IgM syndromeFas Ligand (FasL), Apo I Ligand (ApoI L), APTL, APT1LG1, CD95LCD70, CD27 Ligand, CD27LG (CD27L, CD27LG)CD30 Ligand (CD30L, CD30LG), CD1534-1BB Ligand (4-1BBL), CD Antigen 137 Ligand (CD137L)TRAIL, Apo-2 Ligand (Apo2L), TL2RANK Ligand (RANKL), TRANCE, OPGL, ODFTWEAK, DR3LG, APO3-Ligand (APO3L)APRIL, TALL2BAFF, BLyS, THANK, TALL1, DTLLIGHT, LTg, HVEM-Ligand (HVEM-L)TL1A, TL1, VEGIAITR Ligand (AITRL), TL6, GITRL Ligand (GITRL)BAFF, BLyS, THANK, TALL1, DTL, TNFSF13BFunctional NamesTNF Receptor Type I (TNFR1), TNFAR, TNF-R55, TNFR60, p55-R, p55TNFR, p55, CD120aTNF Receptor Type II (TNFR2), CD120b, p75, TNF-R, TNFR80, TNF-R75, TNFBR, p75TNFRTNFR2-RP, CD18, TNFR-RP, TNFCR, TNF-Receptor Type III (TNFR3)OX40, ACT35, TXGP1LCD40 (Receptor), p50, Bp50Fas, CD95, Apo-1, APT1DcR3, M68, TR6CD27, Tp55, S152CD30 , Ki-1, D1S166E4-1BB (Receptor), CD137, ILADR4, Apo2, TRAIL Receptor 1 (TRAILR1)DR5, TRAIL Receptor 2 (TRAIL-R2), KILLER, TRICK2A, TRICKBDcR1, TRAILR3, LIT, TRIDDcR2, TRUNDD, TRAILR4RANK (Receptor), ODFR, TRANCE ROsteoprotegerin (OPG), PRG, OCIF, TR1TNFRSF12 (bovine)TWEAK Receptor (TWEAKR), FN14DR3LTACIBAFFRHVEM, ATAR, TR2, LIGHTR, HVEANGFR, p75NTKBCMA, BCMAITR, GITR, GITR-DTROY, TRADE, TAJRELTDR6SOBa, Tnfrh2, 2810028K06Rik, DcTRAIL R2mSOB, Tnfrh1, DcTRAIL R1DR3, Apo-3, TRAMP, LARD, TR3, WSL-1, TNFRSF12TNFRH3INFORMATION & TECHNICAL SUPPORTBestellungen: Deutschland: Tel: 0800 436 99 10 • email: info@peprotech.dePour commander: France: Tel: +33 (0)1 46 24 58 20 • email: info@peprotechfr.comTo Order: NORDIC: Tel: +46 (0)8 640 41 07 • email: info@peprotech.se145
www.peprotech.com<strong>2011</strong>-<strong>2012</strong> <strong>Catalogue</strong>TGF-β SuperfamilyNatural Antagonists/Name Synonyms Main Function Binding ProteinsINFORMATION & TECHNICAL SUPPORTTGF-β 1Differentiation inhibiting Regulates cell proliferation, growth, differentiation Follistatin, Follistatinfactor, cartilage-inducing and motility. Involved in adipogenesis, -like related genefactor chondrogenesis, embryogenesis, tissue remodeling, (FLRG), Decorin,wound healing and tumor formation.alpha-2macroglobulinTGF-β 2Glioblastoma-derived Regulates cell proliferation, growth, differentiation Decorin, alpha-2T-cell suppressor factor, and motility. Involved in adipogenesis, macroglobulinBSC-1, Cetermin,chondrogenesis, embryogenesis, tissue remodeling,Polyerginwound healing and tumor formation.TGF-β 3None Regulates cell proliferation, growth, differentiationand motility. Involved in adipogenesis,chondrogenesis, embryogenesis, tissue remodeling,wound healing and tumor formation.TGF-β 4Endometrial bleeding asso- Essential for left-right (L-R) asymmetryciated factor beta-4, (EBAF) determination of organ systems. Possible role inLefty preproprotein, LEFTA endometrial bleeding.Inhibin A Inhibin alpha & beta A Inhibits secretion of follitropin by the pituitarygland, regulates embryogenesis, osteogenesis,hematopoiesis, reproductive physiology andhormone secretion from the hypothalamic,pituitary and gonadal glands.Inhibin B Inhibin alpha & beta B Inhibits secretion of follitropin by the pituitarygland, regulates embryogenesis, osteogenesis,hematopoiesis, reproductive physiology andhormone secretion from the hypothalamic,pituitary and gonadal glands.Activin A Activin beta-A, Inhibin Regulates embryogenesis, osteogenesis, Follistatin,beta-1, FRP, (Follicle- hematopoiesis, reproductive physiology and Follistatin-likestimulating hormone- hormone secretion from the hypothalamic, pituitary related gene (FLRG),releasing protein),FSH- and gonadal glands. GASP-1, Cerberus,releasing protein, FSH-DAN, alpha2releasing factor, EDFmacroglobulin.(Erythroid differentiation factor)Activin AB Activin beta A & beta B Regulates embryogenesis, osteogenesis,hematopoiesis, reproductive physiology andhormone secretion from the hypothalamic, pituitaryand gonadal glands.Activin B Activin beta-B, Inhibin Regulates embryogenesis, osteogenesis,beta-2hematopoiesis, reproductive physiology andhormone secretion from the hypothalamic, pituitaryand gonadal glands.Activin C Activin beta-C, Inhibin Regulates embryogenesis, osteogenesis,beta-C, blastocyst B1 hematopoiesis, reproductive physiology andhormone secretion from the hypothalamic, pituitaryand gonadal glands.Activin E Activin beta-E, Regulates embryogenesis, osteogenesis,inhibin-beta Ehematopoiesis, reproductive physiology andhormone secretion from the hypothalamic, pituitaryand gonadal glands.BMP-2 BMP-2A Induces cartilage and bone formation, plays a Noggin, Chordin,role in cardiac morphogenesis.Follistatin,Follistatin-like relatedgene (FLRG), DAN,Cerberus, GremlinBMP-3 Osteogenin Induces cartilage and bone formation.146To Order: EC: Tel: +44 (0)20 7610 3062 • email: info@peprotech.co.ukBestellungen: AUSTRIA: Tel: +43 (0)1 405 9696 • email: info@peprotech.atObjednávky: Česká Rep.: Tel: +420 225 992 284 • email: info@peprotech.cz