Acute Hepatitis Including Acute Liver Failure

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Autoimmune Hepatitis - Acute Presentation Incidence & Diagnostic Criteria 30- 40% of cases present as acute hepatitis /acute liver failure (Czaja & Freese 2002, Lohse 2011) Increasing prevalence of AIH as a cause for acute liver failure (Fujiwara 2011) • ? May reflect improved recognition Autoantibodies unreliable in the diagnosis of acute AIH • Autoantibodies and hypergammaglobulinaemia may not be present at the time of presentation with acute AIH (Lohse 2011) • Autoantibodies present in up to 40% of patients with other causes of acute liver failure - e.g viral or drug-induced (Bernal 2007, Reuben 2010)
Autoimmune Hepatitis - Acute Presentation Histological Features Acute presentation of chronic liver disease • 14-35% have features of chronic hepatitis (Fujiwara 2011, Yasui 2011) • 10-95% have bridging fibrosis or cirrhosis (Nikias 1994, Burgart 1995, Miyake 2010, Fujiwara 2011)
Page 1 and 2: Acute Hepatitis Including Acute Liv
Page 3 and 4: Acute Liver Failure (ALF) FHF and L
Page 5 and 6: Acute Liver Failure Admissions Birm
Page 7 and 8: Acute Liver Injury Establishing the
Page 9 and 10: Acute Liver Injury Establishing the
Page 11 and 12: Case 1
Page 13 and 14: Liver Biopsy in Acute Hepatitis His
Page 17 and 18: Case 1 - ductular reaction CK7 immu
Page 21 and 22: Case 1 (PAS-diastase)
Page 23 and 24: Acute Hepatitis Hepatocyte Prolifer
Page 25 and 26: Case 1 (HVG)
Page 27: Case 1 Diagnosis • Acute hepatiti
Page 31 and 32: Case 1- outcome • Treatment with
Page 33: Case 2 LIVER BIOPSY
Page 39 and 40: Case 2 - outcome • Mild encephalo
Page 41 and 42: Case 2. Macroscopic Appearances Shr
Page 46 and 47: Could this be cirrhotic?
Page 51 and 52: Other Changes Seen in Areas of Pare
Page 53 and 54: Hepatectomy Specimen - Case 2 Histo
Page 55 and 56: Role of Liver Biopsy in Acute Hepat
Page 57 and 58: Acute versus Chronic Damage Severe
Page 59 and 60: Liver Cell Death in Acute Hepatitis
Page 61 and 62: Acute Hepatitis - Common Causes 1.
Page 63 and 64: Acute Hepatitis - Aetiological Cons

Acute Hepatitis Including Acute Liver Failure

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