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Acute Hepatitis Including Acute Liver Failure

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<strong>Acute</strong> <strong>Liver</strong> Injury<br />

Establishing the Aetiology<br />

Blood tests<br />

• routine biochemistry<br />

‣hyperacute (high transaminases, lower bilirubin)<br />

• paracetamol, ischaemia, hepatitis B<br />

‣subacute (lower transaminases, higher bilirubin)<br />

• seronegative hepatitis<br />

‣Wilson’s disease (low alkaline phosphatase)<br />

• paracetamol detection<br />

• viral serology<br />

‣IgM antibodies to HAV, HBV, HEV<br />

• liver immunology<br />

‣autoantibodies, immunoglobulins

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