Prototyping of microfluidic systems with integrated ... - DTU Nanotech

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Publications and patents The following publications have resulted from this Ph.D. project: Peer reviewed articles: [P1] Frederik Bundgaard, Gerardo Perozziello, and Oliver Geschke. Rapid prototyping tools and methods for all-Topas® cyclic olefin copolymer fluidic microsystems. Proc. IMechE Part C: Journal of Mechanical Engineering Science, 220(C11):1625-1632, 2006. [P2] Frederik Bundgaard, Jörg Vogel, and Oliver Geschke. Rapid prototyping of optical waveguides in multi-layer COC/Topas microfluidic systems. In preparation. [P3] Gerardo Perozziello, Frederik Bundgaard, and Oliver Geschke. Fluidic Interconnections for Microfluidic Systems: A new integrated fluidic interconnection allowing plug’n’play functionality. Submitted to Sensors and Actuators. [P4] Theodor Nielsen, Daniel Nilsson, Frederik Bundgaard, Peixiong Shi, Peter Szabo, Oliver Geschke, and Anders Kristensen. Nanoimprint lithography in cyclic olefin copolymer (COC), a highly UV-transparent and chemical resistant thermoplast. Journal of Vacuum Science and Technology B, 22(4):1770–1775, 2004. Conference proceedings: [C4] Frederik Bundgaard, Gerardo Perozziello, and Oliver Geschke. Rapid prototyping methods for all-COC/Topas®Waveguides and viii
microfluidic systems. In Klavs Jensen, Jongyoon Han, D. Jed Harrison, and Joel Voldman, editors, ”Proceedings of the µTAS 2005 9th International Conference on Miniaturized Systems for Chemistry and Life Sciences”, volume 2, pages 1200–1202. The Royal Society of Chemistry, 2005. [C5] Frederik Bundgaard, Theodor Nielsen, Daniel Nilsson, Peixiong Shi, Gerardo Perozziello, Anders Kristensen, and Oliver Geschke. Cyclic Olefin Copolymer (COC/Topas®) - an exceptional material for exceptional lab-on-a-chip systems. In Thomas Laurell, Johan Nilsson, Klavs Jensen, D. Jed Harrison, and Jörg P. Kutter, editors, Proceedings of the µTAS 2004 8th International Conference on Miniaturized Systems for Chemistry and Life Sciences, volume 2, pages 372–374. The Royal Society of Chemistry, 2004. [C6] Frederik Bundgaard, Jens Ducrée, Roland Zengerle, and Oliver Geschke. Prototyping of multilayer waveguides with V-grooves in COC/Topas®. In Wolfgang Menz, Bertrand Fillon, and Stefan Dimov, editors, Proceedings of the 4M2006 Second International Conference on Multi-Material Micro Manufacture, pages 75–78. Elsevier, 2006. [C7] Frederik Bundgaard, Gerardo Perozziello, and Oliver Geschke. Rapid prototyping of all-COC/Topas® fluidic microsystems. In Wolfgang Menz and Stefan Dimov, editors, Proceedings of the 4M2005 First International Conference on Multi-Material Micro Manufacture, pages 405–407. Elsevier, 2005. [C8] Frederik Bundgaard. Recent Developments in Microfluidic Systems in Polymers. In Proceedings of Medical Plastics 2006 Conference, online proceedings available on www.hexagon.dk, 2006. [C9] Frederik Bundgaard. Microfluidic Systems in Polymer Materials – Research, Prototyping and Integration. In Proceedings of Medical Plastics 2005 Conference, online proceedings available on www.hexagon.dk, 2005. ix
Page 1 and 2: Prototyping of Microfluidic Systems
Page 3 and 4: Preface This thesis is one of the r
Page 5 and 6: joining the substrate, optical laye
Page 7 and 8: Disse metoder inkluderer: • Mikro
Page 9: Many thanks to the collaborators in
Page 13 and 14: Contents Preface i Abstract ii Resu
Page 15 and 16: CONTENTS xiii 5 Optical waveguides
Page 17 and 18: Chapter 1 Introduction In the last
Page 19 and 20: 1.1 Downscaling 3 Figure 1.1: Scali
Page 21: 1.2 Prototyping of microfluidic sys
Page 24 and 25: 8 Theoretical aspects - microfluidi
Page 26 and 27: 10 Theoretical aspects - microfluid
Page 38 and 39: 22 Polymer materials - mainly Topas
Page 52 and 53: 36 Fabrication methods results are
Page 54 and 55: 38 Fabrication methods An impressiv
Page 56 and 57: 40 Fabrication methods Average roug
Page 58 and 59: 42 Fabrication methods a b c d e 1m
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44 Fabrication methods Generally, t
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46 Fabrication methods branch. Sec-
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48 Fabrication methods and the heig
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50 Fabrication methods Topas on Top
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52 Fabrication methods Table 4.2: C
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54 Fabrication methods Figure 4.8:
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56 Fabrication methods that the str
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58 Fabrication methods the excimer
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60 Fabrication methods 500 µm 500
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62 Fabrication methods wedge tests
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Chapter 5 Optical waveguides in Top
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5.1 Waveguide fabrication 67 It sho
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5.2 Propagation loss measurements 6
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5.3 Thermal treatment of the surfac
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5.4 Optical cuvette absorbance meas
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5.4 Optical cuvette absorbance meas
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5.5 A refractive index sensor 81 fr
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5.5 A refractive index sensor 83 a
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5.6 Summary 85 5.5.3 Improvements I
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Until further notice, Chapter 6 is
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96 Discussion and outlook transpare
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References [1] A. Manz, N. Graber,
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REFERENCES 101 [20] David Walton an
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REFERENCES 103 [41] Kiha Lee and Da
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REFERENCES 105 prototyping of polym
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REFERENCES 107 [81] M. Grumann, J.
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