Prototyping of microfluidic systems with integrated ... - DTU Nanotech

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x Publications and patents [C10] Christian Bergenstof Nielsen, Gerardo Perozziello, Frederik Bundgaard, Bjarne Helbo, P. Torben Tang, and Oliver Geschke. Microfluidic systems in polymers performing chemical analysis. In Proceedings of Medical Plastics 2004 Conference, online proceedings available on www.hexagon.dk, 2004. [C11] Theodor Nielsen, Daniel Nilsson, Frederik Bundgaard, Peixiong Shi, Oliver Geschke, Peter Szabo, and Anders Kristensen. Nanoimprint lithography of Topas, a new thermoplast with excellent properties for lab-on-a-chip applications. In Tecnical Digest of the 48th International Conference on Electron, Ion, and Photon Beam Technology and Nanofabrication, pages 165–166, 2004. [C12] Gerardo Perozziello, Martin F. Jensen, John McCormack, Frederik Bundgaard, and Oliver Geschke. Plug’n’pump fluidic interconnection. In Thomas Laurell, Johan Nilsson, Klavs Jensen, D. Jed Harrison, and Jörg P. Kutter, editors, Proceedings of the µTAS 2004 8th International Conference on Miniaturized Systems for Chemistry and Life Sciences, volume 2, pages 575–577. The Royal Society of Chemistry, 2004. [C13] O. Geschke, M. F. Jensen, F. Bundgaard, C. B. Nielsen, and L. H. Christensen. Polymer microstructures: are they applicable as optical components? In Proceedings of the SPIE - The International Society for Optical Engineering, volume 5591, page 13. 2004.
Contents Preface i Abstract ii Resumé iv Acknowledgements vi Publications and patents viii Contents xi 1 Introduction 1 1.1 Downscaling . . . . . . . . . . . . . . . . . . . . . . . . . 2 1.2 Prototyping of microfluidic systems . . . . . . . . . . . . 4 2 Theoretical aspects – microfluidics and optics 7 2.1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . 7 2.2 Fluidics and microfluidics . . . . . . . . . . . . . . . . . 8 2.2.1 Mixing in microfluidics . . . . . . . . . . . . . . . 11 2.3 Waveguide optics . . . . . . . . . . . . . . . . . . . . . . 12 2.3.1 Snell’s law . . . . . . . . . . . . . . . . . . . . . . 13 2.3.2 Planar waveguides . . . . . . . . . . . . . . . . . 14 2.3.3 Waveguide bends . . . . . . . . . . . . . . . . . . 15 2.3.4 Tapered waveguides . . . . . . . . . . . . . . . . 15 2.3.5 Theory and practice . . . . . . . . . . . . . . . . 17 2.4 Optical measurements in microfluidics . . . . . . . . . . 17 2.4.1 Planar microfluidics . . . . . . . . . . . . . . . . 19 2.5 Summary . . . . . . . . . . . . . . . . . . . . . . . . . . 20 xi
Page 1 and 2: Prototyping of Microfluidic Systems
Page 3 and 4: Preface This thesis is one of the r
Page 5 and 6: joining the substrate, optical laye
Page 7 and 8: Disse metoder inkluderer: • Mikro
Page 9 and 10: Many thanks to the collaborators in
Page 11: microfluidic systems. In Klavs Jens
Page 15 and 16: CONTENTS xiii 5 Optical waveguides
Page 17 and 18: Chapter 1 Introduction In the last
Page 19 and 20: 1.1 Downscaling 3 Figure 1.1: Scali
Page 21: 1.2 Prototyping of microfluidic sys
Page 24 and 25: 8 Theoretical aspects - microfluidi
Page 26 and 27: 10 Theoretical aspects - microfluid
Page 38 and 39: 22 Polymer materials - mainly Topas
Page 52 and 53: 36 Fabrication methods results are
Page 54 and 55: 38 Fabrication methods An impressiv
Page 56 and 57: 40 Fabrication methods Average roug
Page 58 and 59: 42 Fabrication methods a b c d e 1m
Page 60 and 61: 44 Fabrication methods Generally, t
Page 62 and 63:
46 Fabrication methods branch. Sec-
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48 Fabrication methods and the heig
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50 Fabrication methods Topas on Top
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52 Fabrication methods Table 4.2: C
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54 Fabrication methods Figure 4.8:
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56 Fabrication methods that the str
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58 Fabrication methods the excimer
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60 Fabrication methods 500 µm 500
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62 Fabrication methods wedge tests
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Chapter 5 Optical waveguides in Top
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5.1 Waveguide fabrication 67 It sho
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5.2 Propagation loss measurements 6
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5.3 Thermal treatment of the surfac
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5.4 Optical cuvette absorbance meas
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5.4 Optical cuvette absorbance meas
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5.5 A refractive index sensor 81 fr
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5.5 A refractive index sensor 83 a
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5.6 Summary 85 5.5.3 Improvements I
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Until further notice, Chapter 6 is
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96 Discussion and outlook transpare
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References [1] A. Manz, N. Graber,
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REFERENCES 101 [20] David Walton an
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REFERENCES 103 [41] Kiha Lee and Da
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REFERENCES 105 prototyping of polym
Page 117 and 118:
REFERENCES 107 [81] M. Grumann, J.
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