Database on medicinal plants used in ayurveda - AYUSH Research ...

Alcoholic extract of root of I. racemosa was reported to possess potent antiallergic
properties (Srivastava et al., 1999).
TOXICOLOGY
The approximate LD50 of root extract was 2030 � 35 mg/kg i.p. in mice. The
LD50 of extract (whole plant) was 250 mg/kg i.p. in rats (Sharma et al.,
1978).
THERAPEUTIC EVALUATION
In clinical trials on 30 patients of bronchial and 14 patients of chronic
spasmodic bronchitis, I. racemosa showed improvement in pulmonary
functions, haematological picture and general health (Singh et al., 1983). In
another clinical study on 9 patients of ischaemic heart disease, prior
treatment of the patients with powdered drug (in dosage of 3 gm, orally)
could prevent post exercise ST segment depression in all the cases. The
observations were comparable with those of nitroglycerine (Tripathi et al.,
1984b). A test drug (Lipistat) comprising of equal-proportions of extracts of
Terminalia arjuna, I. racemosa Hook. and latex of Commiphora mukul is
also reported to be useful in the prevention of ischemic heart disease (Seth et
al., 1998).
A combination of oleoresin of Commiphora mukul and I. racemosa has been
clinically tried in 50 patients of ischaemic heart disease. The combination
was administered in a dose of 6g per day, in three divided dose for a period
of 4 months. In a trial 5 patients were cured i.e., they did not have pricordial
pain and the serum cholesterol and ECG were within normal limits after 4
months treatment. Varying degree of improvement was observed in 40
patients while in 5 there was no improvement (Tripathi et al., 1984b).
Kasadamana – a composite drug prepared from 3x tincture of Adhatoda
vasica, Clerodendron serratum, Inula racemosa and Solanum
xanthocarpum was investigated in 62 cases of kasa. The drug has shown
encouraging results in new cases of kasa especially kaphaja variety. It has
been proved to be an effective expectorant (Abhang and Kulkarni, 1989).
150 patients of coronary heart disease treated with puskara guggulu powder
for a period of six months at total dose level of 6-8g per day in divided doses,
exhibited most efficacious Lipid lowering activity (Singh et al., 1991).
Haritaki vati (HT) is composed of seven herbal drugs such as Terminalia
chebula, Acorus calamus, Pluchea lanceolata, Piper longum, Zingiber
officinale, Hedychium spicatum and Inula racemosa. 20 patients were
administered 2 tablets of HT orally, TDS for 2 months and observations
were made. The gradation of chest pain was found to be shifted towards less
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