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When citing an abstract from the 2009 Annual - Society for ...

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Disclosures: J. Andersen, None; Å. Ripel, None; F. Boix, None; P. Norm<strong>an</strong>n, None; J.<br />

Morl<strong>an</strong>d, None.<br />

Poster<br />

551. Behavioral Pharmacology I<br />

Location: South Hall A<br />

Time: Tuesday, October 20, <strong>2009</strong>, 8:00 am - 12:00 noon<br />

Program#/Poster#: 551.2/Y5<br />

Topic: C.17.cc. Addiction: Behavioral pharmacology<br />

Support: NIH K99 ES015428<br />

NIH T32 ES007326<br />

NIH R01 ES015687<br />

Title: Discriminative stimulus effects of cocaine in rats following developmental exposure to<br />

polychlorinated biphenyls (PCBs)<br />

Authors: *H. J. SABLE 1 , S. MONAIKUL 2 , E. POON 2 , P. A. EUBIG 3 , S. L. SCHANTZ 4 ;<br />

1 Psychology, Univ. Memphis, Memphis, TN; 2 Neurosci. Program, 3 Vet. Biosci., 4 Neurosci.<br />

Program <strong>an</strong>d Vet. Biosci., Univ. Illinois at Urb<strong>an</strong>a-Champaign, Urb<strong>an</strong>a, IL<br />

Abstract: Exposure to <strong>the</strong> ubiquitous environmental contamin<strong>an</strong>t polychlorinated biphenyls<br />

(PCBs) c<strong>an</strong> result in a number of hum<strong>an</strong> health concerns. Developmental exposure to PCBs in<br />

rats has been shown to produce alterations in brain dopamine (DA) concentrations that persist<br />

into adulthood. These alterations suggest <strong>the</strong> rein<strong>for</strong>cing properties of drugs of abuse that act on<br />

<strong>the</strong> DA system may be affected by developmental PCB exposure. The current study was<br />

conducted to determine if <strong>the</strong> interoceptive effects of cocaine <strong>an</strong>d d-amphetamine would be<br />

altered by developmental exposure to <strong>an</strong> environmentally relev<strong>an</strong>t PCB mixture. Female Long-<br />

Ev<strong>an</strong>s rats were orally exposed to 0, 3 or 6 mg/kg/day PCBs beginning 4 weeks prior to breeding<br />

<strong>an</strong>d continuing until litters were we<strong>an</strong>ed on postnatal day 21. One adult male <strong>an</strong>d female per<br />

litter were trained to discriminate cocaine (10.0 mg/kg, i.p.) <strong>from</strong> saline by repeatedly pairing<br />

cocaine injections with rein<strong>for</strong>cement on one response lever, <strong>an</strong>d saline injections with<br />

rein<strong>for</strong>cement on <strong>the</strong> o<strong>the</strong>r lever. Once <strong>the</strong> training criterion was met, each rat was given a series<br />

of generalization tests (three replicates/dose) to four lower doses of cocaine (1.25, 2.5, 5.0, <strong>an</strong>d<br />

7.5 mg/kg) <strong>an</strong>d four doses of amphetamine (0.125, 0.25, 0.50, <strong>an</strong>d 1.0 mg/kg), as well as crossgeneralization<br />

tests following 5.0 mg/kg of <strong>the</strong> non-DA mediated drug pentobarbital (all<br />

administered i.p.). Overall, PCB exposure signific<strong>an</strong>tly altered <strong>the</strong> interoceptive properties of <strong>the</strong>

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