PELONEWS Spring/Summer 2023
Enjoy our Newsletter with FOCUS ON EXTRAVESICULAR RESEARCH Organoids and organ-on-a-chip 3-in-1 Plate a new 3D Cell Culture Technology Extracellular Matrices: ExtraGel, an equivalent to Matrigel and Defined Solutions Liver Cells/ Hepatocytes New suppliers and products
Enjoy our Newsletter with FOCUS ON EXTRAVESICULAR RESEARCH
Organoids and organ-on-a-chip
3-in-1 Plate a new 3D Cell Culture Technology
Extracellular Matrices: ExtraGel, an equivalent to Matrigel and Defined Solutions
Liver Cells/ Hepatocytes
New suppliers and products
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PELONews <strong>Spring</strong>/<strong>Summer</strong> <strong>2023</strong><br />
Overview Extracellular Matrix (ECM)<br />
The Extracellular Matrix (ECM) is a vital component found in all tissues and organs, serving as a<br />
structural framework for cells and playing a crucial role in tissue development, differentiation, and<br />
maintenance. It provides essential biochemical and biomechanical signals necessary for proper tissue<br />
morphogenesis and homeostasis. Genetic abnormalities in ECM proteins can lead to a wide range of<br />
syndromes, varying in severity. As a result, targeting ECM molecules has become a significant focus<br />
in pharmacotherapy. Various diseases arise due to ECM abnormalities, including Osteoarthritis,<br />
cancer, genetic disorders like Marfan's syndrome, and even acquired conditions like coronary heart<br />
disease.<br />
Extracellular Matrices & Hydrogels products for R&D or GMP<br />
• Gelatin<br />
• Speed Coating Solution<br />
• PhenoDrive<br />
• Collagen (I, II, III, IV)<br />
• Fibronectin (human plasma derived; also available in GMP quality and virus inactivated)<br />
• Laminin/iMatrix 221 for Cardiomyocytes& Myoblasts, 411 for Endothelial Cells), 511 for ES/iPS<br />
cells)<br />
• Vitronectin<br />
• ECM Mixtures<br />
• Scilia ExtraGel<br />
• Alternatives to Matrigel and organ & cell culture derived ECMs<br />
Productlist ECMs: https://www.yumpu.com/en/document/read/62911690/portfolio-ecm-products<br />
12 I www.pelobiotech.com