- Page 1 and 2: \ ?^p 6r.1 CELL CYCLE CONTROL OF HU
- Page 3 and 4: In tho narn€ of Alah, olt G6cloua
- Page 5 and 6: Acknowl6dg6msnts Contents Abstract
- Page 7 and 8: Selection ol cell linss contalning
- Page 9 and 10: ACKNOWLEDGEMENTS
- Page 11 and 12: I would also lkg ro rhank Dr. Pafic
- Page 13 and 14: ABSTRACT
- Page 15 and 16: i.leraclion elem€nt, sil6 ll, Thr
- Page 17 and 18: 8. Colony hybridizalion sc.eening o
- Page 19 and 20: INTRODUCTION
- Page 21 and 22: t t F: con cda c@tot d H. G@ r@Mbn
- Page 23 and 24: Azh F: C6n Ca/cro C@t.t ot H. G.n.
- Page 25 and 26: Aziz f: Celi Ctcle Cotutol ol H4 Ae
- Page 27 and 28: = 2. q t6l tl9t E L:I la-lf titl I.
- Page 29 and 30: En F. Ce Cycl. Cantd d h. Gft ra.sc
- Page 31 and 32: ,r1z F Cett cy.te connot ol H4 Gene
- Page 33 and 34: A2i2F: Cettcdt cotubtot e@IrNiotid
- Page 35 and 36: Ntz F: Ce Cwte Contd d 114 Gm tansc
- Page 37 and 38: t- s- i;> f z x + n q e o, { T T z
- Page 39 and 40: AzzF cett Crct. ContolatH4Gen ldn*t
- Page 41 and 42: a2i2 F cdt c$t. connd d H4 Gm Tdnsc
- Page 43 and 44: o rl$orrE GEIE FEEI{IXU =; FrN -!r
- Page 45 and 46: !e 3lhllrllon c.I cycl. control aa
- Page 47: A.E F: Cet CEl. Cotuot ot H4 t3.M f
- Page 51 and 52: 9C| -= = , o:li?eiP :< :::? il il 7
- Page 53 and 54: s.tudi. dhcrm or do"rn! -l /4 I I I
- Page 55 and 56: aziz F: cel crd. cotuot d 81 cd. fn
- Page 57 and 58: a2lz F: celt cyd. c.ntol d H4 G@. f
- Page 59 and 60: A2iz F Cett cycta contat al Hl Gene
- Page 61 and 62: E2 F. cen crct. Connat al H4 c*e Ta
- Page 63 and 64: Colony hybridization 4a aa a a
- Page 65 and 66: ,dd f . c.t cfi|e cotud d H4 cd'e f
- Page 67 and 68: Restriction Analysis Of Mutants e'b
- Page 69 and 70: ,d, F: ccl crc!. cqfrol ot H10d fdt
- Page 71 and 72: AtIzF: Cd CJ.L Cdtuotol BaGq:€lat
- Page 73 and 74: ,.8 F: 6t W @tlol o, rk 0.,t rn',df
- Page 75 and 76: ldD F: Cett CrL Cotuot at t14 G* Iw
- Page 77 and 78: A2E F. cdt crcto Cantat at Ha Gqa r
- Page 79 and 80: Aziz F: Cdl Ced. Cd*ol ol H4 Gse ra
- Page 81 and 82: o E o !!tH I rtog 5l €s c_g - t-
- Page 83 and 84: kir F: cettctttd contal at H4 cen.
- Page 85 and 86: arE F: CeI Crct Cotuatat 114 G40 fa
- Page 87 and 88: c A B e'l' t i _ f '', \J..$.'
- Page 89 and 90: Nz F: Cel Ctd. Ctuol at h4 Cq. faBd
- Page 91 and 92: Aziz F: Celt Cyct. Contd d H4 6@e l
- Page 93 and 94: azE F. celt cy.b contol al H4 Gene
- Page 95 and 96: A Geneticin (G4'18) rssistanl HeLa
- Page 97 and 98: NizF: Cen qcb cttuat al tu G@ ft|tl
- Page 99 and 100:
M F: Cd W W.l h. 4.. 7'.t'll'Pn'd F
- Page 101 and 102:
'dit F: ce qcle cotuot ol Ha Gm ra@
- Page 103 and 104:
M. F: Ce|| Crd. Cqnrot ot Ha Gerc T
- Page 105 and 106:
azi. F: cetl cttcL ctu.t or Ha Gtu
- Page 107 and 108:
kiz F: c.lt
- Page 109 and 110:
ktz F. cen ctct6 ctuat at tu 6e rft
- Page 111 and 112:
Azi2 F: Cen Cvcte Contot .t H4 Gere
- Page 113 and 114:
I 200000 1mmo DNA Synth.3l3 In Sync
- Page 115 and 116:
High mitotic index alter relsase tr
- Page 117 and 118:
ND F Cen atct6 cannot ot B4 6ene rr
- Page 119 and 120:
NE F: Cell C6t cotuat .t H4 cffi fh
- Page 121 and 122:
A22 F: Cett cytl. Connd d H4 64. rn
- Page 123 and 124:
hnF cet cyttd cannot ot B4 6end ltu
- Page 125 and 126:
Nuclear Run-on TranscriPlion wr Fol
- Page 127 and 128:
NlzF Cett cr.t. canuat oI H4 Gene f
- Page 129 and 130:
RNA isolated f rom cell synchrony H
- Page 131 and 132:
A2iz F: c.u cwL contat al Ha GeN f@
- Page 133 and 134:
RESULTS
- Page 135 and 136:
trb F: cett clcL cotuot al H4 Gen.
- Page 137 and 138:
M2F:Co Crrt6 Cdrtot ot H4G.n. fn.pi
- Page 139 and 140:
HiNF-tvl HiNF-P HiNF-D random DNA p
- Page 141 and 142:
andom DNA poly G/C competitor oligo
- Page 143 and 144:
a2i2 F: ceu ctcte contol al H4 Gene
- Page 145 and 146:
aziz F: c.ll crd. cdtd 0t H4 Gene t
- Page 147 and 148:
compeutor oligonucleolides: Site ll
- Page 149 and 150:
A1i2 F: Ceu a:rcte cotuot ot H1 G@
- Page 151 and 152:
andom DNA poly G/C competilor oligo
- Page 153 and 154:
EEF:Ce Olcta Cont t ol114 Gene l@ns
- Page 155 and 156:
, F: cal qcb cotfrtl d rh 9.n ftuaf
- Page 157 and 158:
kL E d N. Cdfr.t ol k e.rE ltlr&tu
- Page 159 and 160:
Mt F: Cett C\.1e Catud cn Ha Ger. I
- Page 161 and 162:
A.*F: Cen q.h cdtuotot Ha 6an ranfl
- Page 163 and 164:
3!j{99!caaw arir c",. r_*rooo FI9 3
- Page 165 and 166:
I -a2b F: cel cyde c@xol d B1 aa@ h
- Page 167 and 168:
-= GAPDH mRNA = = 012 66 hours afle
- Page 169 and 170:
Fq *' I E t li! lil tlr ilt Frlr li
- Page 171 and 172:
(! (! t- (Y) F o 'F (E d z l t52 +
- Page 173 and 174:
E Comparison ol TgT9 ratios lor cAT
- Page 175 and 176:
Azd F: Cd Ctcle Ca\ttol ot ltt Gtuf
- Page 177 and 178:
:tE &I qiE{, ccaoi oftaa Cer tir fi
- Page 179 and 180:
kEE@q.l.co''o,a,tl,od,',rutg/bt!,.
- Page 181 and 182:
ibEc|,Otd.c!,'t,dlHao'tllep,rcl Fg.
- Page 183 and 184:
DrscussroN
- Page 185 and 186:
I azz F Con CYb Cnror ot H4 G@e ntn
- Page 187 and 188:
,@2 F. Cdt CEle Cotud .l U1 G.N fan
- Page 189 and 190:
l NE P C.l qE/€ Cotud d H4 Gw f@f
- Page 191 and 192:
aznF:couct l. cdtold H16@f@tioti@ s
- Page 193 and 194:
ari2 F: c.t] cyctd contnt ot H1 Ger
- Page 195 and 196:
Atiz F. Cdl cycl6co.ttol d H4 Gene
- Page 197 and 198:
l A2izF C.ttctct (onntt ot a. calo
- Page 199 and 200:
azi. F: cei c\cb cotuot d H4 G@ fon
- Page 201 and 202:
NizF Can a$t. c@tot ot H4 G.n fftNc
- Page 203 and 204:
Atiz F: Catl Cvcte contot ol H4 6.n
- Page 205 and 206:
Aztz F a.tt ctcte conr ot .t Hl 6en
- Page 207 and 208:
,rit 9: Ceu Cycle C.htot ot Ha C.n6
- Page 209 and 210:
tai. F: ceu cycte cantat ot ,r1 Gen