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LNCS 2950 - Aspects of Molecular Computing (Frontmatter Pages)

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320 Solomon Marcus<br />

identified with the spatio-temporal organization <strong>of</strong> gene expressions through the<br />

control <strong>of</strong> DNA folding patterns via conformational (or noncovalent) interactions,<br />

while the second articulation is identified with the linear arrangement <strong>of</strong><br />

nucleotides to form structural genes through covalent (or configurational) interactions.<br />

Ji rediscovers another duality at the level <strong>of</strong> proteins, where the second<br />

articulation is identified with covalent structures, while the first articulation is<br />

identified with the three-dimensional structures <strong>of</strong> polypeptides formed through<br />

conformational (or noncovalent) interactions. As it can be seen, for Ji there are<br />

a total <strong>of</strong> four articulations <strong>of</strong> the genetic language and the condition <strong>of</strong> linearity<br />

and sequentiality <strong>of</strong> a language structure is no longer satisfied. The concept <strong>of</strong> a<br />

language as a special sign system is in question, and it is no longer clear where<br />

is the border, if there exists such a border, between an arbitrary sign-system<br />

and a language-like sign system. Both Martinet [13] and Lyons ([9] page 74-76)<br />

stress the link between duality and arbitrariness. Duality points out to some<br />

limits <strong>of</strong> the arbitrariness <strong>of</strong> the linguistic sign. Can we speak, equivalently, <strong>of</strong><br />

the arbitrariness <strong>of</strong> the “genetic sign”? To what extent is heredity the result <strong>of</strong><br />

the combinatorial game expressed by the first articulation, under the limits and<br />

the freedom imposed by the second articulation?<br />

References<br />

1. Bel-Enguix, G. <strong>Molecular</strong> <strong>Computing</strong> Methods for Natural Language Syntax, PhD<br />

Thesis, 2000, Univ. <strong>of</strong> Tarragona, Spain.<br />

2. Collado-Vides, J. A syntactic representation <strong>of</strong> units <strong>of</strong> genetic information. J.<br />

Theor. Biol. 148 (1991) 401–429.<br />

3. Collado-Vides, J. The elements for a classification <strong>of</strong> units <strong>of</strong> genetic information<br />

with a combinatorial component. J. Theor. Biol., 163 (1993) 527–548.<br />

4. Freund, R., Kari, L., Păun, Gh. DNA computing based on splicing: the existence<br />

<strong>of</strong> universal computers. Theory <strong>of</strong> <strong>Computing</strong> Systems, 32 (1999) 69–112.<br />

5. Head, T. Formal language theory and DNA: an analysis <strong>of</strong> the generative capacity<br />

<strong>of</strong> specific recombinant behaviors. Bull. Math. Biol. 49 (1987) 737–739.<br />

6. Head, T. Splicing schemes and DNA, in Lindenmayer Systems: Impact on Theoretical<br />

Computer Science and Developmental Biology (G. Rozenberg, A. Salomaa,<br />

eds.) Springer-Verlag, Berlin, (1992) 371–383.<br />

7. Head, T., Păun, Gh., Pixton, D. Language theory and molecular genetics, Chapter<br />

7inHandbook <strong>of</strong> Formal Languages (G. Rozenberg, A. Salomaa, eds.), vol. 2 (1997)<br />

295–360.<br />

8. Ji, S. The Bhopalator: an information/energy dual model <strong>of</strong> the living cell (II).<br />

Fumndamenta Informaticae, 49 1/3 (2002) 147–165.<br />

9. Lyons, J. Semantics I. Cambridge Univ. Press, 1997.<br />

10. Marcus, S. Linguistic structures and generative devices in molecular genetics.<br />

Cahiers de Ling. Theor. et Appl., 11 1 (1974) 77–104.<br />

11. Marcus, S. Language at the crossroad <strong>of</strong> computation and biology. In <strong>Computing</strong><br />

with Bio-molecules: Theory and Experiments (Păun, Gh., ed.), Springer-Verlag,<br />

Singapore, (1998) 1–35.<br />

12. Martinet, A. La double articulation linguistique. Travaux du Cercle Linguistique<br />

de Copenhague, 5 (1949) 30–37.

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