NIH Research Festival 2012 Program - Research Festival - National ...

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Concurrent Symposia Session I Natcher Conference Center Balcony B Gene and neuronal networks implicated in behavioral and cognitive deficits associated with neuropsychiatric disorders Co-Chairs: Andres Buonanno, NICHD; and Zheng Li, NIMH Cognitive dysfunction and altered behavioral traits are common features of numerous neuropsychiatric disorders and Williams Syndrome; however, little is known about how the development and function of the underlying neuronal networks affected. The purpose of this symposium is to emphasize how the convergence of basic, translational and clinical research, encompassing studies from rodents to humans, has begun to identify how the genetic underpinnings manifest as an early developmental profile of transcriptomes in schizophrenia, how genes identified as risk factors for neuropsychiatric disorders can regulate the development and function of neuronal networks and behaviors associated with these illnesses, and how functional MRI and PET are beginning to uncover the association of genes with cognition. The potential identification of critical gene nodes (comprised of numerous psychiatric “at risk” genes) that converge to influence the activity and interconnectivity of neuronal circuits may uncover novel circuit-based targets for treatment of psychiatric illness. Joel Kleinman, NIMH Human brain development and risk for schizophrenia David Chen, NIMH Whole exome sequencing in the first degree cousin pairs with early age-at-onset bipolar disorder FARE Award Winner Zheng Li, NIMH A new look at dopamine D2 receptors in schizophrenia Andres Buonanno, NICHD Neuregulin regulates neuronal network activity and behaviors associated with psychiatric disorders Kuan Hong Wang, NIMH Mechanisms of experience-dependent regulation of prefrotnal circuitry Karen Berman, NIMH Neurogenetic mechanisms in Williams syndrome: from genes to neural circuits to behavior and back again 20 Tuesday, October 9, <strong>2012</strong> 3:00 p.m.–5:00 p.m.
Concurrent Symposia Session I Natcher Conference Center Balcony C Tuesday, October 9, <strong>2012</strong> 3:00 p.m.–5:00 p.m. Development of neuroimaging based biomarkers Co-Chairs: Barry Horwitz, NIDCD; and Richard Coppola, NIMH The three fundamental steps necessary for the clinical management of a brain disorder are (1) detection and diagnosis, (2) treatment, and (3) assessment of treatment response. Biomarkers are important for the first and third of these, and may provide targets for treatment. Importantly, a biomarker refers to the underlying disease state, not to the symptoms of a disorder per se. In this symposium, the focus will be on attempts to develop neuroimaging biomarkers for detection, diagnosis and treatment assessment. In particular, neuroimaging can potentially provide both structural and functional brain biomarkers. Recently, advances in neuroimaging have shifted attention from examining individual brain regions to focusing on brain networks, and neuroimaging biomarker development has followed this shift. Speakers will discuss various uses of neuroimaging biomarkers, as well as some specific applications to neurologic and psychiatric disorders. Barry Horwitz, NIDCD What can brain based biomarkers be used for? James Blair, NIMH fMRI biomarkers for differentiating forms of Conduct Disorder Brian Cornwell, NIMH Markers of cortical plasticity in antidepressant action Silvina Horovitz, NINDS State-dependent and disease related variations in functional networks Richard Coppola, NIMH Tracking brain network changes during training and cognitive remediation Samuel Hasson, NINDS Next-generation therapeutic avenues for neurodegenerative disease: Targeting Pink1 and Parkin to modulate mitochondrial quality control FARE Award Winner 21
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