NIH Research Festival 2012 Program - Research Festival - National ...

Concurrent Symposia Session IV
Natcher Conference Center
Conference Room E1/E2
Translational Research Interest Group (TRIG)
Common molecular mechanisms underlying
pathogenesis and treatment of human diseases
Co-Chairs: Minkyung (Min) Song, NCI; and Joel Moss, NHLBI
Common pathogenic mechanisms of diverse diseases and similar clinical effects of their
treatment with therapeutic interventions have been identified. It is timely to discuss this
symposium topic as it addresses leveraging previous development of agents by exploring
additional therapeutic indications to those agents that perturb common targets/pathways
in multiple diseases. This topic is of broad interest to the NIH scientists as it facilitates
discovery and development of therapeutic candidates that may benefit patients with
diseases that share common pathogenic pathways. During this symposium, speakers will
discuss: Role of the mammalian target of rapamycin pathway and targeting this pathway in
diverse diseases; Clinical evaluation of an antibody against a common therapeutic target in
several cancers; Exploring additional use of an anti-cancer drug in targeting a downstream
pathway of hemolytic disorders; and Treatment approaches using molecular insights into
pathogenesis of diseases and known mechanisms of action of several approved drugs.
Joel Moss, NHLBI
Mammalian target of rapamycin (mTOR) as a target for therapeutic intervention
in diverse diseases
Ludmila Prokunina-Olsson, NCI
From cancer genetics to translational genomics: Genetic and functional association
of Prostate Stem Cell Antigen (PSCA) gene with several cancers
Gregory Kato, NHLBI
Pleiotropic effects of intravascular hemolysis upon vascular homeostasis
Emily Chew, NEI
Treatment for age-related macular degeneration by targeting diverse pathogenic pathways
David Goldstein, NINDS
Willie Sutton’s getaway car and the pathogenesis of Lewy body diseases
Thursday, October 11, 2012
Noon–2:00 p.m.
71