NIH Research Festival 2012 Program - Research Festival - National ...

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Concurrent Symposia Session III Natcher Conference Center Balcony C 52 Wednesday, October 10, 2012 2:00 p.m.–4:00 p.m. Microbiome Working Group Microbiome research at the NIH: From disease to therapeutics Co-Chairs: Rashmi Sinha, NCI; and Leigh Greathouse, NCI Symposium on Microbiome Research at the NIH: From disease to therapeutics. This symposium will center on current work within the NIH intramural program, and will focus on characterization of the microbiome, etiologic investigations, and the possible use of microorganisms in therapy. The symposium will end with a discussion including the speakers, selected poster presenters, and a panel of experts, which will be lead by the session chairs. The purpose of this discussion will be to address the research needed to advance interdisciplinary work on the microbiome at the NIH so that both basic science and epidemiology are fully integrated. Shruti Naik, NIAID Compartmentalized control of skin immunity by resident commensals Christian Abnet, NCI Upper GI microbiome and mortality Katia Garcia-Crespo, NIAID Lactobacillus-mediated priming of the respiratory mucosa protects against lethal virus infection Laurel Lagenaur, NCI Live biotherapeutic approaches to HIV prevention Noriho Iida, NCI Gut commensal bacteria promote anti-tumor innate immune responses in distant tumors after immunotherapy and chemotherapy FARE Award Winner Poster Blitz: 1. Roberto Flores (NCI) Standardization of specimen collection and handling procedures for gut microbiome analyses; 2. John Grainger (NIAID) Inflammatory macrophages regulate pathologic responses to commensals during acute gastrointestinal infection; 3. Reiko Yamane (NEI) Commensal microbiota as a trigger for ‘Spontaneous’ Autoimmune Uveitis
Concurrent Symposia Session III Natcher Conference Center Conference Room D Matrix biology and matrix remodeling Chair: Keir Neuman, NHLBI Wednesday, October 10, 2012 2:00 p.m.–4:00 p.m. Extra-cellular matrices provide the structural underpinning of human form and function. Cells comprising human tissues are embedded in, and supported by, extracellular matrices composed of collagens, proteoglycans, and associated proteins. Mineralized matrices form the basis for the skeletal system, including cartilage and teeth. Matrix scaffolds are deposited and remodeled by resident cells providing an organized milieu that in turn exerts multiple effects on cell activity, including differentiation and migration. Physiological processes including development, morphogenesis, and wound healing are associated with matrix formation and remodeling. Pathologies including atherosclerosis, metastatic invasion and rheumatoid arthritis are associated with misregulation of remodeling, whereas bone and connective tissue disorders are associated with matrix protein mutations. This symposium will bring together NIH investigators from diverse research areas who share a common interest in the extra cellular matrix and how it is remodeled. Kenneth Yamada, NIDCR Matrix regulation of signaling, cell migration, and development Rinki Ratna Priya, NEI Exome sequencing and association analysis implicates extracellular matrix gene, FBN2 in early and late onset macular degenerations FARE Award Winner Sergey Leikin, NICHD Procollagen folding and misfolding in the cell Larry W. Fisher, NIDCR Understanding the abnormal trafficking of mutant DSPP in dentin diseases suggests a new class of cargo receptor(s) for exiting the endoplasmic reticulum Herbert Geller, NHLBI The sour side of sugars: Overcoming chondroitin sulfate proteoglycans to promote axonal regeneration in the CNS Keir C. Neuman, NHLBI Single-molecule tracking of collagenase on native type I collagen fibrils reveals degradation mechanism 53
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