NIH Research Festival 2012 Program - Research Festival - National ...

Concurrent Symposia Session III
Natcher Conference Center
Balcony B
Wednesday, October 10, 2012
2:00 p.m.–4:00 p.m.
Cell Cycle Interest Group
Mitosis: From molecular detail to human disease
Co-Chairs: Mary Dasso, NICHD; and Ji Luo, NCI
Mitotic chromosome segregation is a fundamental process that assures genomic
stability in all eukaryotes. Moreover, controlled cell division plays a key role in the
specification of many cell fate choices and helps to govern the size, structure and
shape of tissues. Mitotic defects cause human diseases, particularly cancers, and
underlie some forms of infertility. This symposium will focus on the diverse range of
novel approaches that are being developed throughout the NIH to understand this
critical process, from mathematical modeling of regulatory circuits to the identification
of therapeutic targets based upon mitotic deficiencies of cancer cells. (Four of these
speakers are tenure-track investigators.)
Chairperson Information
Orna Cohen-Fix, NIDDK
Nuclear structure deformation during mitotic arrest in budding yeast
Petr Kalab, NCI
Mitotic RanGTP gradient promotes mitotic progression in normal and cancer cells
and is amplified by chromosomal gain
Indu Kohaar, NCI
Allele-specific mRNA and protein expression on genetic variants of CCNE1 associated
with risk of bladder cancer
FARE Award Winner
Jian Liu, NHLBI
Spatio-temporal regulation of checkpoints in mitosis
Ji Luo, NCI
The Ras synthetic lethal gene ERH controls chromosome congression and the splicing
of the mitotic motor protein CENP-E
Nasser Rusan, NHLBI
Centrosome maturation in asymmetric divisions
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