NIH Research Festival 2012 Program - Research Festival - National ...

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Concurrent Symposia Session II Natcher Conference Center Conference Room E1/E2 Translational research in addiction, stress, and anxiety Co-chairs: Yavin Shaham, NIDA; and Andrew Holmes, NIAAA We will present translation research performed at NIAAA, NIDA, and NIMH. Holmes (NIAAA) will present mouse and human studies showing that pharmacological inhibition and genetic variation in an enzyme degrading the endocannabinoid anandamide promotes trauma recovery and predicts stress coping. Cameron (NIMH) will present rodent studies showing that inhibiting adult neurogenesis prolongs stress response and increases anxiety/depressive-like behavior. She will also show that ketamine, a rapidly-acting antidepressant, could act via new neurons. Grillon (NIMH) will present rat and human studies on functional dissociation between fear and anxiety. He will then discuss the implications of this dissociation for clinical anxiety research. Shaham (NIDA) will present rat studies using the reinstatement model that have inspired human studies on the effect of pharmacological and learning manipulations on drug craving. Heilig (NIAAA) will present mouse, rat, monkey, and human studies supporting a ‘kindling’ process, controlled in part by genetic susceptibility, which promotes alcoholism. The implications of these studies to personalized alcoholism treatment are discussed. Michelle Jobes, NIAAA Development and field demonstration of software for delivery of contingency management - an empirically supported behavioral treatment for addiction FARE Award Winner Andrew Holmes, NIAAA Convergent translational support for the role of endocannabinoids in processing fear and stress Heather Cameron, NIMH New neurons in the adult dentate gyrus buffer stress response and anxiety/depression-like behavior Christian Grillon, NIMH Distinguishing anxiety from fear: from basic science to clinical studies Yavin Shaham, NIDA Translational research based on the reinstatement model of drug relapse: recent progress Markus Heilig, NIAAA Pharmacogenetics and the role of stress for excessive alcohol intake 26 Wednesday, October 10, <strong>2012</strong> 10:00 a.m.–Noon
Concurrent Symposia Session II Natcher Conference Center Balcony A Drosophila Neurobiology Interest Group Mapping neural circuits and functions Co-Chairs: Chi-Hon Lee, NICHD; and Wei Li, NEI Systems neuroscience traditionally concentrates on the computational/algorithmic level of the nervous system, as David Marr advocated over three decades ago. How the brain implements these neural computations, especially in neuronal connections, is largely unknown. Even less is know about how mis-wiring of the brain during development contributes to neurological disorders, such as schizophrenia and autism. Recent technical advancements provide new venues to tackle the implementation problem directly. Microscopic reconstruction maps detailed neuronal connections at the synaptic level. Genetic methods enable activity manipulation of highly selected neurons and the identification of key circuit elements for specific functions. Kevin Briggman, NINDS Modern 3D electron microscopy for mapping neuronal circuit connectivity Harold Burgess, NICHD A circuit breaking screen identifies gsx1 expressing neurons as modulators of the startle response Benjamin White, NIMH Mapping an elementary decision network in Drosophila Wednesday, October 10, <strong>2012</strong> 10:00 a.m.–Noon Mihaela Serpe, NICHD Drosophila Neto controls the assembly and maintenance of glutamatergic synapses at the neuromuscular junction Wei Li, NEI A color coding amacrine cell may provide a “Blue–Off” signal in a mammalian retina Fujun Luo, NINDS Syntaxin 1 modulates activity-dependent inhibition of voltage-gated calcium channels at a central synapse FARE Award Winner 27
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