Products at a Glance 2024

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www.pelobiotech.com IPSCs have been investigated for their use in dentistry, immunotherapy, and as a tool for personalized autologous body organ transplant, showcasing their expanding role in different medical fields (Hynes et al., 2015; Jiang et al., 2013; Palomo et al., 2014). Moreover, iPSCs have been utilized for modeling inherited cardiomyopathies, bone regeneration, and as a platform for drug screening and disease modeling, further emphasizing their broad applications in medicine (Karakikes et al., 2014; Tang et al., 2014; Hwang et al., 2021). The potential of iPSCs in regenerative medicine has also been recognized through the development of liver buds and clinical-grade neural stem cells, highlighting the ongoing efforts to harness iPSCs for clinical applicability (Sekine et al., 2020; Cai et al., 2021). We offer: • Around 10,000 human disease models for preclinical drug development • Diverse models, including spheroid and organoid models, physiological barrier models, and more. • An extensive selection of iPSC derivative cell types, from pericytes to cardiomyocytes, for a wide range of research applications Below is a summary of the cell types we provide. Please note that this list is not exhaustive. To explore our complete cell offerings, we encourage you to request our detailed cell list or visit pelobiotech.com for additional information. iPSC-Derived Cardiomyocytes (Heart): Cardiotoxicity screening for drug development. Studying heart diseases and genetic disorders. Regenerative medicine for cardiac tissue repair. iPSC-Derived Hepatocytes (Liver): Drug metabolism and toxicity testing. Modeling liver diseases and viral infections. Development of bioartificial liver devices. iPSC-Derived Hepatic Stellate Cells and Kupffer Cells (Liver): Investigating liver fibrosis and cirrhosis. Testing anti-fibrotic drugs for liver disease treatment. Understanding hepatic stellate cell biology. iPSC-Derived Neurons (Brain): Modeling neurodegenerative diseases like Alzheimer's Drug discovery and testing for neurological disorders. Studying neural development and function. iPSC-Derived Keratinocytes (Skin): Skin disease modeling, such as epidermolysis bullosa. Wound healing and tissue regeneration studies. Drug testing for dermatological conditions. iPSC-Derived Endothelial Cells: Investigating cardiovascular diseases and vascular disorders. Testing anti-angiogenic drugs for cancer therapy. Vascular tissue engineering and regenerative medicine. iPSC-Derived Kidney Cells: Investigating renal diseases and disorders. Testing personalized medicaments for kidney health. Studying drug responses specific to kidney function iPSC-Derived Hematopoietic Stem Cells (HSCs): Studying blood disorders like anemia and leukemia. Personalized therapies for hematological disorders Drug screening for hematological conditions. iPSC-Derived Hematopoietic Stem Cells (HSCs): Studying blood disorders like anemia and leukemia. Developing personalized cell therapies for blood-related diseases. Drug screening for hematological conditions. iPSC-Derived Immune Cells: Modeling autoimmune diseases and immunodeficiencies. Developing immunotherapies and vaccines. Screening for immunomodulatory drugs and treatments. 10

www.pelobiotech.com Adult Stem Cells Adult stem cells, also known as somatic or multipotent stem cells, are a unique class of undifferentiated cells found within various tissues and organs of the human body. Unlike embryonic stem cells, which can differentiate into any cell type, adult stem cells are more restricted in their potential but still possess the ability to develop into a range of specialized cell types within the specific tissue or organ where they reside as shown in the figure above. However, these cells play a vital role in tissue maintenance. As you can see in the figure they form cells that repair, and aid in regeneration throughout an individual's life, making them a valuable resource for regenerative medicine and research aimed at understanding and treating various medical conditions. We offer the following cells: • Hematopoietic CD34+ stem cells and Mononuclear cells to isolate CD34 or CD113 cells • Available from both males and females, complete with donor clinical status. • Sourced from peripheral blood, cord blood and bone marrow. CD34 is a crucial marker for various progenitor cells, particularly hematopoietic stem cells (HSC) and hematopoietic progenitor cells (Sidney et al., 2014). It plays a significant role in hematopoiesis, as evidenced by its presence in progenitor cells during hematopoiesis, and its potential to give rise to hematopoietic, endothelial cells, and smooth muscle cells (Kapoor et al., 2019; Bai et al., 2009). CD34 has been linked to cellular homing patterns to the bone marrow and adhesion of cells to stromal microenvironments or sites of inflammation (Kopher et al., 2010). Furthermore, CD34(+) stem cells have been found to play an important role during liver development and regeneration (Park et al., 2015). Additionally, CD34 has been associated with the regulation and compartmentalization of stem cells, promoting their adhesive interactions with the stromal microenvironment of the bone marrow (Healy et al., 1995). It has also been identified as a marker for hematopoietic stem cells and non-hematopoietic progenitors, including vascular endothelial progenitors and embryonic fibroblasts, multipotent mesenchymal stromal cells, interstitial dendritic cells, and epithelial progenitors (Soliman, 2021). Moreover, CD34 has been utilized as an important marker for labeling hematopoietic stem cells, demonstrating its significance in stem cell research and applications (Ye et al., 2004). Mesenchymal/Stromal Stem cells Mesenchymal stromal cells (MSCs), often called mesenchymal stem cells, are adult stem cells found in bone marrow, adipose, Wharton jelly and other tissues. Notable characteristics include: • Differentiation into various cell types, such as bone, cartilage, and fat cells. • Immune system modulation, making them valuable for treating autoimmune diseases, inflammatory conditions, and tissue damage. • Regenerative properties that promote tissue repair. 11